Qualitative analysis of scopolamine-induced amnesia |
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| Authors: | Eric D. Caine Herbert Weingartner Christy L. Ludlow Edward A. Cudahy Susan Wehry |
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| Affiliation: | (1) Departments of Psychiatry and Neurology, University of Rochester Medical Center, Rochester, New York, USA;(2) Laboratory of Psychology and Psychopathology, National Institute of Mental Health, Bethesda, Maryland, USA;(3) Communicative Disorders Branch, National Intitute of Neurological and Communicative Diseases and Stroke, Bethesda, Maryland, USA;(4) Syracuse University, Syracuse, New York, USA;(5) Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts, USA;(6) University of Rochester Medical Center, 300 Crittenden Boulevard, 14642 Rochester, NY, USA |
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| Abstract: | The neurochemistry of memory remains to be determined. Acetylcholine may be one of the neuotransmitters which mediates memory function, since the anticholinergic drug scopolamine produces amnesia in man. This study of scopolamine-induced memory deficits further defines those cognitive processes which are disrupted. The drug does not diminish attention, as assessed with an auditory vigilance task, or initial signal detection. More complex auditory decoding is affected, however. Scopolamine impairs aspects of initial memory acquisition (e. g., encoding and consolidation) and spontaneous memory retrieval. Retention is unaffected. Precise delineation of the neurochemistry of human memory will require comparative studies of amnesia-producing compounds, systematically examining the neuropsychological processes impaired by each. |
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| Keywords: | Scopolamine Drug-induced amnesia Memory and learning Anticholinergic effects |
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