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| 不同剂量valsartan应用对SHR血压和左室心肌肥厚的影响 | |
| 引用本文： | 汤海,胡作英,杨霆. 不同剂量valsartan应用对SHR血压和左室心肌肥厚的影响[J]. 中国临床药理学与治疗学, 2001, 6(1): 12-14 |
| 作者姓名： | 汤海 胡作英 杨霆 |
| 作者单位： | 1. 南京医科大学，南京 210009 2. 南京医科大学附属南京第一医院 3. 皖南医学院弋矶山医院 |
| 摘 要： | 目的评价不同剂量ATi受体拮抗剂valsartan对SHR的降压疗效及其逆转心肌肥厚作用的影响。方法18只14周龄雄性SHR随机分成空白对照组、小剂量valsartan组、大剂量valsartan组，另设WKY正常对照组，分别给予生理盐水、valsartan8mg |
| 关 键 词： | 高血压 自发性高血压大鼠 缬沙坦 左室心肌肥厚 |
| 修稿时间： | 2000-10-04 |
Effect of different dosesof valsartan on blood pressure and left ventricular hypertrophy in spontaneouslyhypertensive rats |
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| TANG Hai,HU Zuo-Ying,YANG Ting. Effect of different dosesof valsartan on blood pressure and left ventricular hypertrophy in spontaneouslyhypertensive rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2001, 6(1): 12-14 | |
| Authors: | TANG Hai HU Zuo-Ying YANG Ting |
| Affiliation: | TANG Hai HU Zuo_Ying1 YANG Ting2 |
| Abstract: | Aim To evaluate the effects of different doses of valsartan on blood pressure and left ventricular hypertrophy in spontaneously hypertensive rats (SHR) . Methods Eighteen SHR (fourteenweek-old, male) were divided into three groups (six rats in each group ): SHR control group in which the rats were fed with normal saline; low dose valsartan group in which the rats were fed with valsartan 8 mg· kg-1 · d-1 and high dose valsartan group in which the rats were fed with valsartan 24 mg · kg -1 · d-1, all for 8 weeks. The rats in the WKY control group (n ＝ 6) were fed with normal saline for 8 weeks. Results SBP, LVM/ BW and TDM of SHR were remarkably lower than those of the control after drug intervention, and the effect on SBP, LVM/ BW and TDM was most remarkable in the high dose valsartan group. Conclusion Different doses of valsartan can decrease SBP of SHR and inhibit the progression of ventricular hypertrophy. |
| Keywords: | hypertension spontaneously hypertensive rat (SHR) valsartan left ventricular hypertrophy |
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