填精补血化瘀口服液对实验性动脉硬化鹌鹑纤溶活性的影响及机理研究

填精补血化瘀口服液具有升高食饵性动脉硬化（Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ，ＡＳ）鹌鹑血浆组织型纤溶酶元激活物（ＴｉｓｓｕｅＰｌａｓｍｉｎｏｇｅｎａｃｔｉｖｉｔｏｒ，ｔ－ＰＡ）活性，降低纤溶酶元激活物抑制物（Ｐｌａｓｍｉｎｏｇｅｎａｃｔｉｖｉｔｏｒｉｎｈｉｂｉｔｏｒ，ＰＡＩ）活性；调整二者活性比，恢复纤溶系统功能。其作用机理可能与该方药减少动脉壁脂质沉积，改善血液流变性，减轻动脉内膜损伤，保护平滑肌细胞及内皮细胞功能活动有关．因而，该方药对治疗ＡＳ，尤其是防止ＡＳ的恶化，都具有积极意义。

Study on the Effect and Mechanism of Tianjing Buxue Huayu OralLiquid in Fibrinolytic Activity of Atherosclerosic Quails

The expement showed that Tianjing Buxue Huayu Oral Liquid (TJHYOL) restored tile fibtinolytic function of atherosclerosic quails by raising the activity of tissue plasminogen activator (t-PA), reducing the activity of plasminogen activator inhibitor (PAI) and regulating their activity ratio. The pharmacological mechanism is that TJHYOL reduces the amount oflipid deposition in arterial wall and blood viscosity. So it can protect the intravascular membranecells and maintain the function of fibrinolysis system. According to the experiment research, wethink TJHYOL is an ideal drug for treating and preventing atheroselerosis.