First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae |
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Authors: | Gieffers Jens Rupp Jan Gebert Andreas Solbach Werner Klinger Matthias |
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Affiliation: | Institute of Medical Microbiology and Hygiene, University of Lübeck, 23538 Luebeck, Germany. Jens.Gieffer@hygiene.ukl.mu-luebeck.de |
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Abstract: | Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence. |
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