圆锥角膜的研究进展

圆锥角膜是一种常见、非炎症性、双眼发病的角膜扩张性疾病，以中央部角膜变薄、瘢痕形成为特征，严重影响视力，病因至今不十分明确，可能是多因素的，如胶原学说、遗传学说、上皮学说等。目前最新的研究致力于圆锥角膜病的基因研究，并认为是主要的病因之一。实验室研究表明，酶和蛋白酶抑制因子的降解、白细胞介素-1系统在发病机制中扮演重要角色，但仍有待于进一步研究。圆锥角膜的临床表现十分典型，但要早期诊断需借助角膜地形图。角膜接触镜是最普遍的治疗形式，当患者不能接受接触镜时，穿透性角膜移植是最佳的也是最有效的选择。

Study progression of keratoconus

Keratoconus is a relatively common, bilateral, non-inflammatory corneal ectasia characterized by thinning and scarring of the central portion of the cornea,seriously destroyed the vision. The aetiology of this condition is probably multiple factors,such as collagen themry,genetic themry,epithelia themry,etc.Now,recent investigations devote to gene,and think it one of the major aetiological factors. Laboratory studies suggest a role for degradative enzymes and proteinase inhibitors and a possible role for the interleukin-1 system in its pathogenesis, but these roles need to be more clearly defined. It has well-described clinical signs, but early forms of the disease may go undetected unless the anterior corneal topography is studied. Contact lenses are the most common treatment modality. When contact lenses fail, corneal transplant is the best and most successful surgical option.