动态血压监测厄贝沙坦治疗高血压的临床疗效

目的 研究厄贝沙坦治疗原发性轻中度高血压的临床疗效及安全性。方法 入选40例原发性轻中度高血压患者，随机分为两组，分别给予厄贝沙坦或贝那普利治疗4wk，每2wk随访一次，并于服药前后进行24h动态血压监测（ABPM）。结果 厄贝沙坦降压总有效率达85．0％，ABPM结果提示其对夜间收缩压和舒张压均有显著性降低（P〈0．05），同时不影响血压昼夜节律及心率，无明显不良反应发生。结论 厄贝沙坦降压疗效显著且平稳，安全性好。

The clinical effect of irbesartan on hypertension assessed by ambulatory blood pressure monitoring

Objective To investigate the clinical effect and safey of irbesartan on essential mild to moderate hypertension . Methods Forty patients with essential mild to moderate hypertension were enrolled and arranged randomly to two groups.They were treated with irbesartan or benazepril respectively for 4 weeks and visited every two weeks .24-hour ambulatory blood pressure monitoring (ABPM) was performed before and after drug administration .Results The total efficacy rate of irbesartan was 85.0% .The night systolic and diastolic blood pressures were reduced significantly observed in ABPM(P<0.01), which were better than benazepril (P<0.05).Blood pressure rhythm and heart rate were uninfluenced .No obvious adverse reaction occurred. Conclusion The antihypertensive effect of irbesartan is remarkable and stesdy .The safety is also good .