参麦注射液对老年肺心病心功能及血液流变学的影响

目的：观察参麦注射液对老年肺心病急性加重期患心功能及血液流变学影响。方法：78例慢性肺心病急性加重期伴有心功能不全患随机被分为2组，其中40例为观察组，在常规治疗的基础上加用参麦注射液治疗，连续2周；对照组38例仅予常规治疗，治疗前、后以多普勒超声心动图评定心功能，并进行血液流变学检测。结果：观察组患经参麦注射液治疗后心排量、心脏指数、射血分数均显增加(P＜0．01)。同时血液流变学示全血粘度、血浆比粘度、红细胞聚集指数、红细胞电泳时间、红细胞比积、血小板聚集率、纤维蛋白原定量均显下降(P＜0．01或P＜0．05)，其心功能与血液流变学的改善均明显忧于对照组(P＜0．05)。观察组临床总有效率及显效率分别为90．0％及50．0％；明显高于对照组的71.1％及26．3％(P＜0．05)。治疗期间未见明显副作用。结论：参麦注射液能显改善肺心病急性加重期患的心功能及血液流变性，是治疗肺心病的一种有效而安全的药物。

Effects of shenmai injection on cardiac function and hemorheology in patients with acute exacerbation of senile chronic pulmonary heart disease

Objective: To observe effects of shenmai injection (SMI) on cardiac function and hemorheology in patients with acute exacerbation of senile chronic pulmonary heart disease (CPHD). Methods: Seventy-eight cases of CPHD complicated cardiac dysfunction were divided randomly into observation group (40 cases) and control group (38 cases). The observation group was treated with combined therapy of SMI and conventional medicines, the control group was treated with conventional medicine only? there were 2 weeks for therapy course in both 2 groups. Cardiac function was assessed by pulsed Doppler echocardiography and the parameters of hemorheology were measured before and after therapy. Results: In observation group, cardiac output., cardiac index and ejection fraction were significantly increased (P<0. 01 all) and observation on hemorheology showed that whole blood viscosity under low or high shear state, plasma viscosity, erythrocyte aggregation index, erythrocyte electrophoresis time and hematocrit, platelet agglutinate rate and fibrinogen after SMI treatment were meekly reduced (P<0. 01 or P<0. 05), the improvement of cardiac function and hemorheology in observation group were better than those of the control group (P<0. 05). The clinical total effective rates and obvious effective rates in observation group were 90. 0% and 50. 0% respectively; they were higher than those of control group (71. 1% and 26. 3%). There was obvious difference between 2 groups (P< 0.05). No severe adverse effect was found in treating with SMI. Conclusion: SMI can obviously improve cardiac function and blood hemorheology in patients with acute exacerbation of CPHD. It is one of effective and safe drug for treatment of CPHD.