三七总皂甙对Sprague-Dawley种系大鼠脑循环的影响

研究三七总皂甙（ＰＮＳ）对麻醉Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ（ＳＤ）大鼠脑循环的影响，并与维拉帕米（Ｖｅｒ）和去甲肾上腺素（ＮＥ）进行比较。用电磁流量计测定脑血流量（ＣＢＦ），以股动脉平均血压（ＭＢＰ）除以ＣＢＦ为脑血管阻力（ＣＶＲ），结果为：ＰＮＳ５０～２００ｍｇ·ｋｇ－１　ｉｖ使大鼠的ＭＢＰ和ＣＶＲ分别下降１４～２１％和８～２２％，Ｖｅｒ３０ｕｇ·ｋｇ－１ｉｖ表现出类似效应，而ＮＥ３０ｕｇ·ｋｇ－１　ｉｖ则表现出相反效应，对ＣＢＦ，ＰＮＳ１００和２００ｍｇ·ｋｇ－１使其分别减少１５±１１％和３３±１０％，而Ｖｅｒ和ＮＥ均对其无影响。表明ＰＮＳ虽具扩张ＳＤ大鼠脑血管的作用，但并不因此而增加ＳＤ大鼠的脑血流量。

Effects of Panax Notoginseng Saponins on Cerebral Circulation in Anesthetized Sprague-Dawley Strain Rats

In sodium pentobarbital anesthetized Sprague-Dawley strain rats, mean bloodpressure (MBD) and cerebrovascular resistance (CVR) fell by 14-21% and 8-22% (P<0. 05, n =5 ) respectively after Panax notoginseng saponins (PNS) 50-200 mg.kg-1 iv, While verapamil(Yer) 30 ug.kg-1 Iv showed a similar effect to PNS,and Norepinephrine (NE) 30 ug.kg- 1 iv gavethe opposite one. PNS also produced a decreasing effect on the cerebral blood flow, but Verand NE didn't. The above results indicate that PNS and Ver are vasodilators of brain bloodvessel, but NE is a vasoconstricator of brain blood vessel.