| 2－萘酚对小鼠免疫功能影响的实验研究 |
| |
| 引用本文： | 许松山,姜万春,刘文生,王家健.2－萘酚对小鼠免疫功能影响的实验研究[J].工业卫生与职业病,1995(2). |
| |
| 作者姓名： | 许松山 姜万春 刘文生 王家健 |
| |
| 作者单位： | 吉林化学工业公司职业病防治所 |
| |
| 基金项目： | 国家“八五”期间劳动卫生标准研制计划课题 |
| |
| 摘 要： | 研究了２－萘酚对ＢＡＬＢ／Ｃ小鼠免疫功能的影响。结果发现，当小鼠接触５～２０ｍｇ／ｋｇ剂量２－萘酚时，１０ｍｇ／ｋｇ和２０ｍｇ／ｋｇ剂量组的小鼠抗体生成细胞功能和外周血Ｔ淋巴细胞数明显低于对照组（Ｐ＜０．０５），并２０ｍｇ／ｋｇ剂量组的脾重也显著低于对照组（Ｐ＜０．０５）。但是，各剂量组小鼠外周血红细胞和白细胞数、体重及主要脏器病理检查均未见异常改变。可见，２－萘酚对机体免疫功能有一定的抑制作用。
|
| 关 键 词： | 2－萘酚 免疫功能 抗体生成细胞 T淋巴细胞 |
EFFECT OF 2-NAPHTHOL ON THE IMMUNE RESPONSES IN MICE |
| |
| Xu Songshan et al.EFFECT OF 2-NAPHTHOL ON THE IMMUNE RESPONSES IN MICE[J].Industrial Health and Occupational Diseases,1995(2). |
| |
| Authors: | Xu Songshan |
| |
| Abstract: | The effect of 2-naphthol on the immune responses in the BALB/C mice was investigated. Four groups of mice were gavaged to 2-naphthol with 0,5,10,20 mg/kg body weight for four weeks. The results showed that the percentage of T-lymphocytes and the function of antibody producing cell were significantly decreased in 10 and 20 mg/kg dose groups, and the spleen weight was also markedly decreased only in 20 mg/kg dose group. However, the RBC and WBC, body weight gain and structure of the main body organs were not effected by 2-naphthol exposure.These results indicated that the immune responses of mice might be inhibited by 2-naphthol exposure. |
| |
| Keywords: | Naphthol Immune response Antibody producing cell T-lymphocyte |
| 本文献已被 CNKI 等数据库收录！ |
|
