In vitro antisickling activity of cromolyn sodium |
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| Authors: | Ahmedou B K Fall Michèle Toppet Alina Ferster Pierre Fondu Renée Vanhaelen-Fastré & Maurice Vanhaelen |
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| Institution: | Laboratoire de Pharmacognosie et Bromatologie, Institut de Pharmacie de l'UniversitéLibre de Bruxelles (U.L.B),;Unitéd'Hémato-Oncologie, Hôpital Universitaire Des Enfants Reine Fabiola (HUDERF), and Laboratoire d'Hématologie, Hôpital Universitaire Brugmann (U.L.B), Bruxelles, Belgium |
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| Abstract: | The improvement in sickle cell disease (SCD) children receiving cromolyn sodium therapy prompted us to investigate its antisickling activity in vitro . The number of sickle cells was determined in deoxygenated blood samples from 15 children with severe SCD. At the eight concentrations tested, cromolyn sodium exhibited a significantly higher activity than pentoxifylline, the standard compound. Therefore cromolyn sodium would appear to be an interesting candidate for SCD therapy and deserves further in vivo investigations. |
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| Keywords: | cromolyn sodium antisickling activity corpuscular indices |
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