抗核抗体阴性系统性红斑狼疮患者实验室指标与临床症状研究

目的:探讨抗核抗体(ANA)阴性系统性红斑狼疮(SLE)患者的实验室指标及临床症状的特点。方法:总结近五年四川大学华西医院SLE患者39 324例,从中随机选出ANA阴性和ANA阳性SLE患者各200例进行实验室指标及临床症状比较研究。结果:39 324例SLE患者中ANA阴性者占2.08%,其男女比例为1∶4.6,ANA阳性患者男女比例为1∶14.0,两组性别比例差异有统计学意义(P<0.05);两组患者的血液学、肝功能、肾功能、电解质和免疫功能实验室指标中多数指标差异有统计学意义(P<0.05),两组患者临床症状差异均无统计学意义(P>0.05)。结论:ANA阴性SLE患者男性比例显著高于ANA阳性SLE患者的男性患者比例;ANA阴性患者多项实验室指标较ANA阳性患者的更接近正常值,ANA阴性患者无特征性临床表现,该类患者可能是健康人群和典型ANA阳性患者之间的一种过渡阶段。

Analysis of laboratory tests and clinical feature of systemic lupus erythematosus patients with negative antinuclear antibody

Objective:To investigate the laboratory tests and clinical features of the antinuclear antibody (ANA)-negative systemic lupus erythematosus (SLE) patients.Methods:To summarize the 39324 cases of SLE patients in the West China Hospital of Sichuan University in recent five years,we selected ANA negative and ANA positive 200 respectively SLE patients groups and analysed the laboratory tests and clinical features of them.Results:Among the 39 324 cases,2.08％ were ANA negative SLE patients.The proportion of male and female patients in ANA negative SLE group was 1∶4.6,while in ANA positive SLE group male to female ratio was 1∶ 14.0,so the difference was significant(P ＜ 0.05).Lots of laboratory tests of hematology,hepatic function,renal function,electrolyte and immune function in ANA negative SLE patients had significant difference with the ANA positive ones(P ＜ 0.05),but the differences of the clinical features between two groups were not statistically significant (P ＞ 0.05).Conclusion:The proportion of male gender in ANA negative group is much higher than ANA positive group,the laboratory tests in ANA negative group are closer to the normal value than ANA positive group,and there were no characteristic symptoms observed in ANA negative SLE groups.The ANA negative SLE might represent an important intermediate between healthy people and typical ANA positive SLE cases.