玫瑰花水煎剂对小鼠耐缺氧和抗疲劳的实验研究 |
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引用本文: | 刘华,何帅,黄芳俊,赵季军,王明友,周芳名,买文丽. 玫瑰花水煎剂对小鼠耐缺氧和抗疲劳的实验研究[J]. 川北医学院学报, 2017, 32(6): 849-851. DOI: 10.3969/j.issn.1005-3697.2017.06.011 |
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作者姓名: | 刘华 何帅 黄芳俊 赵季军 王明友 周芳名 买文丽 |
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作者单位: | 川北医学院生理教研室,四川南充637000;川北医学院机能中心,四川南充637000;川北医学院2015级临床医学系,四川南充,637000;川北医学院2014级临床医学系,四川南充,637000;川北医学院生理教研室,四川南充,637000 |
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基金项目: | 四川省教育厅项目,省级大创课题,川北医学院校级重点项目 |
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摘 要: | 目的:观察不同浓度的玫瑰花水煎剂对小鼠耐缺氧和抗疲劳的影响。方法:昆明小鼠共60只,随机分为空白对照组(蒸馏水)、玫瑰花水煎剂低剂量组(0.25 g/kg)、玫瑰花水煎剂高剂量组(0.50 g/kg),灌胃给药28 d。检测各组小鼠常温常压耐缺氧时间、负重游泳时间、血中血红蛋白的含量和负重游泳后乳酸含量。结果:与空白对照组相比,高、低剂量组常温常压耐缺氧时间延长,差异有统计学意义(P<0.05);高、低剂量组小鼠负重游泳时间均延长,但低剂量组无显著性差异(P>0.05),高剂量组有统计学意义(P<0.05);高、低剂量组血红蛋白含量均增多,高剂量组差异有统计学意义(P<0.05),低剂量组无显著性差异(P>0.05);负重游泳后,高、低剂量组血乳酸含量均减少,高剂量组差异有统计学意义(P<0.05),低剂量组无显著性差异(P>0.05)。结论:玫瑰花水煎剂能明显提高小鼠耐缺氧和抗疲劳能力。
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关 键 词: | 玫瑰花水煎剂 耐缺氧 抗疲劳 |
Study on the anoxia-resistant and anti-fatigue effect of Rose water decoction on mice |
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Abstract: | Objective:To investigate the anti-hypoxia and anti-fatigue effect of Rose water decoction in mice.Methods:60 Kunming mices were randomly divided into high-dose group(0.50 g/kg),low-dose group ((0.25 g/kg) and blank control group,and administered with drugs at certain doses by gastric perfusion for 28 d.The time of hypoxia tolerance and the time of weight-bearing swimming were measured in each group of mice.The content of hemoglobin in blood and the content of lactic acid after weight swimming were detected.Results:Compared with the blank group,the high and low dose group had a significant difference in the prolonged hypoxia-resistance time in normal temperature(P < 0.05).The weight-bearing swimming time of mice in high and low dose groups was prolonged,but there was no significant difference in the low dose group (P > 0.05),and the high dose group had statistical significance (P < 0.05).The hemoglobin content of high and low dose group was increased,the high dose group had significant difference (P <0.05),and the low dose group had no significant difference (P > 0.05).The content of blood lactic acid decreased after weight-bearing swimming,and the change in high dose group was more than the low dose group.Conclusion:The decoction of rose water can remarkably improve the ability of anti-fatigue and anoxia-resistant in mice. |
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Keywords: | Rose water decoction Anti-fatigue Anoxia-resistant |
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