血浆脑钠肽检测在心力衰竭诊断中的应用评价

目的:探讨血浆脑钠肽(brain natriuretic peptide,BNP)检测在心力衰竭(心衰)诊断中的应用价值。方法:选取心衰患者71例为观察组,同时选取71例健康体检者为对照组,比较两组血浆BNP、左心室射血分数(left ventricular ejection fraction,LVEF)、不同心功能分级BNP水平及阳性检出情况。结果:观察组LVEF比对照组低,血浆BNP水平比对照组高,差异均有统计学意义(P<0.05);观察组心功能Ⅰ级患者血浆BNP阳性检出率53.33%,Ⅱ级阳性检出率76.47%,Ⅲ级阳性检出率95.00%,Ⅳ级阳性检出率100.00%;心功能Ⅳ级患者血浆BNP水平高于Ⅲ级、Ⅱ级及Ⅰ级患者,差异均有统计学意义(t=36.535、24.466、19.305,均P<0.05);心功能Ⅲ级患者血浆BNP水平高于Ⅰ级患者,差异有统计学意义(t=2.732,P<0.05);但心功能Ⅱ级患者血浆BNP水平与Ⅰ级和Ⅲ级比较,差异均无统计学意义(t=1.904、1.104,均P>0.05)。结论:血浆BNP检测在心衰诊断中效果较好,有助于早期诊断,且心衰越严重其阳性检出率与检测值越高。

Clinical evaluation of BNP detection in diagnosis of heart failure

Objective:To investigate the clinical value of brain natriuretic peptide (BNP) in the diagnosis of heart failure.Methods:A total of 71 cases of patients with heart failure were selected as observation group.In the same period,71 healthy subjects were selected as the control group.The levels of BNP,left ventricular ejection fraction (LVEF),BNP grade with different cardiac function and positive rate were compared between the two groups.Results:The LVEF in the observation group was significantly lower than that in the control group,and the levels of BNP was higher than that in the control group,the difference was statistically significant (P ＜0.05).The positive rate of grade Ⅰ was 53.33％,the positive rate of grade Ⅱ was 76.47％,the positive rate of grade Ⅲ was 95.00％,the positive rate of grade Ⅳ was 100.00％.The level of BNP in patients with grade Ⅳ cardiac function was significantly higher than that in grade Ⅰ,Ⅱ and Ⅲ patients,the difference was statistically significant (t =36.535,24.466,19.305,P ＜0.05).The level of BNP in patients with heart function grade Ⅲ was higher than that of patients with grade Ⅰ,and the difference was statistically significant (t =2.732,P ＜ 0.05).However,there was no significant difference between the level of BNP in the patients with cardiac function grade Ⅱ with these in the grade Ⅰ and Ⅲ.Conclusion:BNP detection has a good effect in the diagnosis of heart failure,which is helpful for early diagnosis,and the more serious the heart failure is,the higher the positive detection rate and detection value are.