手足口病患儿临床指标及炎性因子表达水平与患儿年龄的相关性研究

目的:研究手足口病患儿的发病年龄与肝功能指标、心肌指标及炎性因子指标等表达水平的相关性。方法:选取本院2015年1月至2016年12月收治的75例手足口病患儿纳入疾病组,以同期在本院进行健康体检的75例同龄健康儿童作为对照组,对比两组儿童上述各项指标的表达水平;根据年龄将疾病组患儿分为0~2岁亚组、3~6岁亚组、7~12岁亚组,对比不同年龄阶段患儿上述指标的表达特征,并分析患儿年龄与上述各项指标间的相关性。结果:疾病组WBC、TNF-α、hs-CRP均高于对照组(P<0.05)。3亚组间WBC、TNF-α、hs-CRP有统计学意义(P<0.05),而3亚组ALT、AST、CK无统计学意义(P>0.05);经进一步两两对比分析,3亚组间WBC、hs-CRP以及7~12岁亚组与0~2岁亚组、7~12岁亚组与3~6岁亚组间的TNF-α均有统计学意义(P<0.05);但0~2岁亚组与3~6岁亚组间TNF-α无统计学意义(P>0.05)。TNF-α与疾病组患儿年龄具有低度正相关性(0.3≤r<0.5,P<0.05);hs-CRP与疾病组患儿年龄具有中度正相关性(0.5≤r<0.8,P<0.05);WBC与疾病组患儿年龄具有高度负相关性(0.8≤|r|,P<0.05);而ALT、AST、CK与疾病组患儿年龄无统计学相关性(|r|<0.3,P>0.05)。结论:手足口病患儿的发病年龄与ALT、AST、CK、WBC及TNF-α、hs-CRP表达水平间具有一定相关性,在一定程度上揭示了不同年龄阶段患儿的发病特征,临床治疗中应充分考虑这一特征,以提高治疗的针对性,为预防危重手足口病的发生提供指导。

Correlation between the levels of clinical and inflammatory factors and the age of children with hand foot mouth disease

Objective:To study the correlation between the age of onset and the indexes of liver function,the indexes of cardiac muscle and the index of inflammatory factors in children with hand foot mouth disease.Methods:75 cases of children with Hand foot mouth disease(HFMD)in our hospital from January 2015 to December 2016 were included in the mouth disease group,75 cases of healthy age-matched healthy children as control group in our hospital in the same period,the expression level of the above indexes were compared between the two groups of children.According to the age of the disease group were divided into three groups,expression feature comparison the children of different age stages of the above index,and analyzed the correlation between the age and the above indexes between.Results:The levels of WBC,TNF-α and hs-CRP in the disease group were higher than those in the control group (P ＜0.05).There was a statistically significant difference between WBC,TNF-α and hs-CRP alpha in Sanya group (P ＜ 0.05),and ALT,AST and CK analysis showed no significant difference (P ＞ 0.05).After further comparative analysis,WBC,hs-CRP in the Sanya group,7 ～ 12 year old subgroup and 0 ～ 2 year old subgroup,and the TNF-α in 7 ～ 12 year old subgroup and 3 ～6 year old subgroup had statistical significance (P ＜ 0.05),but there was no statistical significance in TNF-α between 0 ～ 2 year old subgroup and 3 ～ 6year old subgroup (P ＞0.05).TNF-α and disease group with age had low positive correlation(0.3≤r ＜0.5,P ＜0.05),hs-CRP and disease group with age had a moderate positive correlation (0.5 ≤ r ＜ 0.8,P ＜ 0.05),WBC and disease groups were highly negative correlation between the age(0.8 ≤ | r|,P ＜ 0.05),and there was no statistical correlation between AST,CK and ALT and disease group with age(| r| ＜ 0.3,P ＞ 0.05).Conclusion:Foot and mouth disease in children of age has certain correlation with ALT,AST,CK,WBC and the expression of TNF-α,hs-CRP,to some extent,it reveals the characteristics of the disease in children of different ages,this feature should be fully considered in clinical treatment,so as to improve the pertinence of treatment and provide guidance for the prevention of severe hand foot mouth disease.