| 内皮素1和前列环素在脑梗死病变过程中的相互作用 |
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| 引用本文： | 闵连秋,李侠,姜文大,马维艳,杨丽,李芳,刘学文,张静波.内皮素1和前列环素在脑梗死病变过程中的相互作用[J].中国组织工程研究与临床康复,2002,6(21):3288. |
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| 作者姓名： | 闵连秋 李侠 姜文大 马维艳 杨丽 李芳 刘学文 张静波 |
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| 作者单位： | First Affiliated Hospital of Jinzhou Medical College，First Affiliated Hospital of Jinzhou Medical College，Jinzhou Central Hospital，First Affiliated Hospital of Jinzhou Medical College，First Affiliated Hospital of Jinzhou Medical College，Jinzhou Central Hospital，First Affiliated Hospital of Jinzhou Medical College，First Affiliated Hospital of Jinzhou Medical College Jinzhou 121001China，Jinzhou 121001China，Jinzhou 121004，China，Jinzhou 121001China，Jinzhou 121001China，Jinzhou 121004，China，Jinzhou 121001China，Jinzhou 121001China |
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| 摘 要： | Inrecentyears,theresearchoftheendocrinefunctionofvas-cularendothelialcellscausedpepole'sextensiveconcern,andal-readydiscoveredthatendothelin-1(ET-1)andprostacyclin(PGI2)ofendothelialcellssecretorytopossesregulatingthetensionofvasculardissepimentandtheproliferationofsmoothmusclecell.ThemotivethisinvestigationistryingtofindouttheclinicalsignificanceandpathogenesisofplasmaET-1andPGI2inthedevelopmentofis-chemiccerebralinfarction.1Subjectsandmethods1.1Subjects(1)Studygroup:Therewere37patients,…
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Interaction of endothelin-1 and prostacyclin during pathological process in patients with ischemic cerebral infarction |
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| MIN Lian-qiu ,LI Xia ,JIANG Wen-da ,MA Wei-yan ,YANG Li ,LI Fang ,LIU Xue-wen ,ZHANG Jing-bo.Interaction of endothelin-1 and prostacyclin during pathological process in patients with ischemic cerebral infarction[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2002,6(21):3288. |
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| Authors: | MIN Lian-qiu LI Xia JIANG Wen-da MA Wei-yan YANG Li LI Fang LIU Xue-wen ZHANG Jing-bo |
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| Institution: | 1. First Affiliated Hospital of Jinzhou Medical College,Jinzhou 121001 China
2. Jinzhou Central Hospital,Jinzhou 121004, China |
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| Abstract: | Objective To investigate the interaction and clinical significance of changes in plasma endothelin 1(ET-1)and prostacyclin(PGI2)concentrations in patients with ischemic cerebral infarction.Methods Plasma ET-1 and 6 keto PGF1α (resistant metabolite of PGI2) concentrations were measured in 37 patients(study group) with ischemic cerebral infarction and 34 healthy volunteers(control group) by radioimmunoassay.Results Plasma ET-1 concentrations in patients of study group were markedly higher than that of control group(P< 0.01) and 6 keto PGF1α concentrations in patients of study group were significantly lower than that of control subjects(P< 0.01).Plasma ET-1 concentrations in control subjects were positively correlated with 6 keto PGF1α concentrations and no correlation in the study group.Conclusion Both ET 1 and PGI2 are participated in patho physiologic process of ischemic cerebral infarction.ET 1 is a virulence factor and may play a deleterious role in ischemic cerebral infarction, PGI2 is a conservancy factor and endogenetic antagonist of ET 1.It may provide useful therapy parameter to find out ectogenesis PGI2 or analog for treating the patients with ischemic cerebral infarction with reason. |
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| Keywords: | endothelin-1 prostacyclin ischemic cerebral infarction pathogenesis |
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