降糖精颗粒治疗2型糖尿病疗效观察及机制探讨

目的: 观察降糖精颗粒治疗2型糖尿病的疗效及其降糖机制的初步探讨。 方法: 将40例2型糖尿病患者随机分为降糖精组和对照组。通过8周的观察,比较2组患者血糖、糖化血红蛋白(HbAlc)和中医症状积分的变化。 结果: 2 组用药前各项指标无显著差异;用药后,降糖精组空腹血糖、餐后2 h血糖、HbAlc较治疗前比较有统计学差异(P<0.05);与对照组比较无统计学差异。但治疗8周时降糖精组症状明显减轻,与对照组比较有统计学差异(P<0.05)。 结论: 降糖精颗粒能改善2型糖尿病患者的糖代谢,减轻患者相关中医症状,其机制可能与调节患者的肠促胰素(GLP-1)有关。

Jiangtangjing Granule Treatment of Type 2 Diabetes Clinical Observation and Mechanism Research

Objective: To observe the Jiangtangjing granule in effect of treatment for type 2-diabetes and its hypoglycemic mechanism of the initial study. Method :Forty patients with type 2 diabetes randomly divided into Jiangtangjing group and control group were compared by blood sugar, glycated hemoglobin(HbAlc) and traditional Chinese medicine(TCM) symptoms integral change through the eight weeks observation. Result: There was no significant difference between two groups before using the indicators. After treatment, Jiangtangjing- granule group show significant difference in fasting blood sugar, blood sugar, 2 h postprandial glycosylated hemoglobin( HbAlc) compared with before (P<0.05), no statistical difference compared with control group, but the symptoms of Jiangtangjing granule group patients significantly reduced compared with the control group, there was statistically significant (P<0.05). Conclusion: Jiangtangjing granule can improve the glucose metabolism and relieve the symptoms related to TCM of patients with type 2 diabetes.Its mechanism may be related to the level of incretin pancreatic hormone(GLP-1).