桃红四物汤加减联合化疗治疗气滞血瘀型肺癌

目的: 观察桃红四物汤加减方联合化疗治疗晚期气滞血瘀型肺癌的临床疗效。 方法: 将60例晚期气滞血瘀型肺癌患者随机分为对照组和治疗组各30例。对照组仅采用西医方案化疗,治疗组在对照组的基础上同时给予中药桃红四物汤加减方配合治疗。连续治疗3个月后,观察对照组和治疗组患者治疗前后近期疗效、生活质量改善、体质量变化、外周血象、免疫功能改善以及不良反应发生情况。 结果: 治疗组和对照组总有效率分别为90.0%,70.0%,治疗组近期疗效明显优于对照组,呈显著性差异(P<0.05);治疗组和对照组患者生活质量提高率分别为60%,40.0%,治疗组明显优于对照组,呈显著性差异(P<0.05);治疗前后治疗组和对照组的体质量变化好转率分别为16.67%,16.67%,无统计学意义;治疗组出现外周血象异常情况明显低于对照组,具有显著性差异(P<0.05);治疗组与对照组治疗前后比较,CD4⁺,CD8⁺,CD4⁺/CD8⁺和NK细胞活性等免疫指标均呈现不同程度的显著性差异(P<0.05或P<0.01),治疗组免疫力明显得到提高;与对照组比较,治疗组不良反应发生率明显低于对照组,呈现显著性差异(P<0.05)。 结论: 桃红四物汤加减方联合化疗药物治疗气滞血瘀型晚期肺癌能有效缓解患者临床症状,提高机体免疫力,减少毒副反应,提高生活质量,两者起到协同增效减毒效果,值得临床推广和应用。

Treatment of Qizhi Xueyu Type Lung Cancer based on Taohong Siwu Soup Plus and Minus Combined with Chemotherapy

Objective: To investigate the clinical efficacy of treatment on the Qizhi Xueyu type lung cancer of Taohong Siwu soup plus and minus combined with chemotherapy. Method: The 60 cases of Qizhi Xueyu type lung cancer in middle and late period were randomly grouped to control group and treatment group, each group for 30 cases. The control groups were only used western medicine chemotherapy scheme, and the treatment groups were cured together with Taohong Siwu soup based on the treatment of control group. After 3 months' treatment continuously, to observe the short term curative effect, the improvement of life quality, the changes of body weight, the improvement of peripheral blood and immune function, and the occurrence of adverse reaction and the survival rates of patients after 1, 3 and 5 years' treatment. Result: The total effectiveness of control group and treatment group were respectively 90.0% and 70.0%, the short term curative effect of treatment group was better than the control group, and there was significant difference(P<0.05); the improvement rate of life quality was respectively 60.0% and 40.0%, the treatment group was better than the control group, and there was significant difference(P<0.05);the improvement rate of body weight was respectively 16.67% and 16.67%, and there was no significant difference; the peripheral blood abnormality rates of treatment group were obviously lower than the control group, and there was significant difference(P<0.05);the treatment and control group were compared before and after treatment, the immune indexes (CD4⁺, CD8⁺, CD4⁺/CD8⁺ and the activity of NK cell) all presented significant difference of different degree(P<0.05 and P<0.01), and the immunity of treatment group was obviously improved; compared with control group, the occurrence rate of adverse reaction of treatment group was obviously lower than control group, and there was significant difference(P<0.05). The survival rates of patients after 1, 3 and 5 years' treatment was better than the control group, and there was significant difference(P<0.05). Conclusion: The Qizhi Xueyu type lung cancer was cured with Taohong Siwu soup plus and minus combined with chemotherapy, and it could effectively relieve the clinical symptoms, improve the immunity, reduce the occurrence of adverse reaction, and improve the life quality, and the TCM combined with chemotherapy had the efficacy improved and toxicity lowered, and it was worthy popularized and applied in clinic.