| 载脂蛋白E基因多态性与缺血性脑血管病的关系 |
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| 引用本文： | 邓芝蕙,叶文翔,姜昭,刘明洲,穆红.载脂蛋白E基因多态性与缺血性脑血管病的关系[J].中国临床神经科学,2000,8(1):29-31. |
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| 作者姓名： | 邓芝蕙 叶文翔 姜昭 刘明洲 穆红 |
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| 作者单位： | 天津第一中心医院脑内科,300192 |
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| 摘 要： | 目的载脂蛋白E(apoE)基因多态性对缺血性脑血管疾病(ICVD)发生的影响。方法临床筛选67例缺血性脑血管病病人，利用聚合酶链反应(PCR)技术进行apoE基因位点的扩增，然后用HhaⅠ酶切DNA扩增产物，进行限制性片断长度多态性分析(RFLP)，检测他们的apoE基因型，并与正常对照组比较，并同时检测血脂水平及血流变学指标。结果ICVD组与健康对照组apoE基因型分布无显著差异，不同类型ICVD组apoE基因型分布亦无显著差异。结论apoE基因多态性不是缺血性脑血管病的危险因素。
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| 关 键 词： | 载脂蛋白E 基因多态性 动脉粥样硬化 缺血性脑血管病 |
| 修稿时间： | 1998-11-25 |
Relationship Between Apolipoprotein E Polymorphism and lschemic Cerebrovascular Disease |
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| DENG Zhi-Hui,YE Wen-Xiang,JIANG Zhao,LIU Ming-Zhou,MU Hong.Relationship Between Apolipoprotein E Polymorphism and lschemic Cerebrovascular Disease[J].Chinese Journal of Clinical Neurosciences,2000,8(1):29-31. |
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| Authors: | DENG Zhi-Hui YE Wen-Xiang JIANG Zhao LIU Ming-Zhou MU Hong |
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| Institution: | DENG Zhi-Hui
,YE Wen-Xiang
,JIANG Zhao
,LIU Ming-Zhou
,MU Hong
(Neurology Department, Tianjin First Central Hospital.Tianjin 300192) |
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| Abstract: | Aim: To investigate the role of apolipoprotein E (apoE) polymorphism in pathogenesis of ischemic cerebrovas- cular disease (ICVD). Methods: We used PCR-RFLP method to detect apoE genotypes of 67 patients with ischemic cere- brovascular disease, and compared it with that of age and sex-matched normal control group. And we detected their plasma lipid levels and hemorheological characteristics at the same time. Results: ApoE polymorphism showed no significant differ- ence between patients and healthy controls. and no difference was found between patients with atherothrombotic stroke and those with lacunar infarction. Conclusion: ApoE polymorphism is not a risk factor for ischemic stroke. |
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| Keywords: | apolipoprotein E gene polymorphism atherosclerosis ischemic cerebrovascular disease |
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