严重急性呼吸综合征患者外周血纤维蛋白原的变化及意义

目的探讨纤维蛋白原(FIB)水平在严重的急性呼吸综合征(Sever acute respiratory syndrome,SARS)中的变化及意义。方法回顾性分析了148例SARS患者外周血纤维蛋白原(Flb)浓度,将148例患者按病程分为初期组(44例)和非初期组(104例)两组;按临床分型分为普通型(87例)和重型(61例)两组;按肺部病变分单叶病变(49例),双叶病变(56例)和弥漫性病变(56例)三组,然后分组进行比较。结果148例SARS患者外周血纤维蛋白原(Flb)水平,其均值(-x±s):522.29±154.87mg/dl,明显高于正常参考值(350mg/dl),差异有统计学意义(P<0.001);初期组血纤维蛋白原水平高于非初期组(P<0.05);随着患者肺部病变范围增大从单叶病变、双叶病变到弥漫性病变,三组患者血纤维蛋白原水平是逐渐升高的(P<0.05)。结论严重急性呼吸综合征(SARS)患者血纤维蛋白原浓度的检测有助于SARS病情的观察和预后的判断,从而提示适时给予纤溶治疗可作为一种提高疗效的尝试。

Changes and significance of peripheral blood fibrinogen levelin patients with severe acute respiratory syndrome

OBJECTIVE: To investigate variations and significance of plasma fibrinogen in patients with severe acute respiratory syndrome (SARS). METHODS: Totally 148 patients with SARS were divided into the following groups: initial stage group (44 cases) and after the initial stage group (104 cases), common type group (87 cases) and severe type group (61 cases), unilobar lung involvement group (49 cases), bilobar lung involvement group (53 cases) and diffuse lung involvement group (46 cases). The values of plasma fibrinogen of the 148 SARS patients were analyzed and compared among the different groups. RESULTS: The mean value of plasma fibrinogen (x +/- SD, 522.29 +/- 154.87 mg/dl) of the 148 cases was higher than the normal value (p less than 0.01). There were significant differences between the initial stage and after initial stage groups, between the common and severe type groups, and among the unilobar, bilobar and diffuse lung involvement groups (p less than 0.05). CONCLUSION: theses results suggested that elevation of peripheral blood fibrinogen in SARS patients may play an important role in development and progress of the disease and its treatment.