缬沙坦对高血压病患者血浆胰岛素水平的影响

目的 观察缬沙坦(商品名代文,瑞士诺华制药有限公司提供)对高血压病(EH)患者胰岛素敏感性的影响。方法 38例高血压病患者根据血压高低分别给予40～80mg,每天一次口服。治疗前及治疗8周后,分别测空腹血糖(FBS)及空腹血浆胰岛素(FSI),计算胰岛素敏感指数(ISI),并与35例性别、年龄、体重指数相同的健康者比较。结果 两组FPG均正常,无显著性差异,EH组治疗前(FSI)显著升高(P<0.01),ISI显著下降(P<0.01)。缬沙坦治疗8周后,FSI显著下降(P<0.05),ISI显著增高(P<0.05)。结论 高血压病患者存在高胰岛素血症,缬沙坦在稳定降压的同时不同程度的改善高胰岛素血症。

The effect of Diovan on the serum insulin level in the patients with hypertension

Objectives To study the effect of Diovan on the insulin sensitivity in patients with hypertension . Methods 38 patients were given 40 ~ 80 mg once a day according their blood pressure. The fasting blood suger (FBS) and fasting serum insulin (FSI) were measured, and calculated the insulin sensitive index (ISI) before and 8 weeks after therapy. The results were compared with 35 health people who had the similar sex, age and weight index. Results The FBS oftwo groups was normal and without significant difference. The FSI was increased(P < 0. 01) and ISI was decreased (P < 0. 01) markedly before therapy in the hypertensive group. The FSI was decreased ( P < 0.05) and ISI was increased (P < 0. 05) markedly after therapy of Diovan. Conclusion The hypertensive patient has hyperinsulinemia. Diovan can improve hy-perinsulinemia and decrease blood pressure stabilizely.