化痰通络方对急性脑梗死大鼠rt-PA溶栓后MMP-9转录活化途径中AP-1与NF-κB基因表达的影响

目的：研究天然冰片对雄性SD大鼠口服尼莫地平药代动力学的影响。方法：大鼠随机分为3组：对照组、天然冰片临床等效剂量组（90 mg·kg^-1）及高剂量组（270 mg·kg^-1），在灌胃给予空白溶媒或天然冰片后各组均口服尼莫地平20 mg·kg^-1，于给药前和给药后不同时间点取血，样品处理后用液相色谱-串联质谱（LC-MS-MS）法测定尼莫地平含量，采用WinNonlin 5.0.1计算药代动力学参数。结果：临床等效剂量的天然冰片对尼莫地平口服吸收无显著影响，高剂量天然冰片使血浆中尼莫地平的浓度-时间曲线下面积（AUC）增大，但与对照组间的差异无统计学意义。结论：高剂量天然冰片可轻微促进尼莫地平的口服吸收，但影响较小。

Effect of Natural Borneol on Pharmacokinetics of Nimodipine in Rats after Oral Administration

Objective: To study the effects of natural borneol (NB) on the pharmacokinetics of nimodipine in rats after oral administration. Method: The rats were randomly divided into three groups, control group, clinically-equivalent-dose group and higher-dose group, and were gavaged with NB at doses of 0, 90, 270 mg·kg^-1, respectively. After 10 min, all rats were gavaged with nimodipine at a dose of 20 mg·kg^-1. The blood was obtained at different time points before and after the administration. Concentrations of nimodipine in plasma were determined by LC-MS-MS and the main pharmacokinetic parameters were calculated by WinNonlin 5.0.1. Result: Clinically equivalent dose of NB showed little influence on the pharmacokinetics of nimodipine. The mean value of AUC in higher-dose group was slightly higher than that in control group, but no significant differences were found between two groups. Conclusion: The results suggested that higher dose of NB may enhance the absorption of nimodipine in rats, but the enhancing effect is not very obvious.