氢氯噻嗪治疗辽宁省阜新地区原发性高血压疗效分析

目的分析氢氯噻嗪治疗辽宁省阜新地区原发性高血压患者的疗效,为低成本控制农村地区高血压提供科学依据。方法随机抽取辽宁省阜新农村地区原发性高血压患者4 511例,给予氢氯噻嗪25 mg,口服1次/d,1个月后测量血压,评价氢氯噻嗪的降压疗效。结果①1个月后得到有效病例4 278例(有效率94.8%),原发性高血压患者治疗后血压平均下降15.8/6.1 mm Hg(P<0.05);②治疗后24.9%的患者血压得到控制,其中男性和女性患者血压控制率分别为21.9%、27.5%(P<0.05)。③不同年龄段35~44岁、45~54岁、55~64岁、≥65岁患者血压控制率分别为28.0%、28.8%、22.1%、22.3%(P<0.05)。④随着血压级别的升高,患者血压控制率逐步下降(36.2%、24.6%、11.2%,P<0.05)。⑤单纯性收缩期高血压患者(738例)血压控制率为35.6%。结论氢氯噻嗪治疗农村地区原发性高血压疗效好,可作为群体降压治疗的一线用药。

Effect of using hydrochlorothiazide to treat rural adults with primary hypertension

Objective To analyze the effect of using hydrochlorothiazide and to find low cost treatment in rural patients with primary hypertension of Liaoning Province.Methods 4 511 patients(age ≥35 yrs) with primary hypertension from Fuxin country in Liaoning province were gathered at random.These patients were treated with hydrochlorothiazide 25 mg every day.After one month,the blood pressure(BP) was measured again.According to these results,the treatment effect of hydrochlorothiazide was evaluated.Results The results of 4 278 patients were analyzed,the response rate was 94.8%.Compared with that before treatment,the mean of decreased BP was 15.8/6.1 mm Hg after treatment.The control rate of primary hypertension was 24.9%(21.9% was in male,27.5% was in female,P<0.05).The control rate went down following BP degree increasing(36.2%,24.6%,11.2%,P<0.05).Furthermore,the control rate was affected by the different period of age(28.0% in 35～44 years,28.8% in 45～54 years,22.1% in 55～64 years,22.3% in over 65 years.P<0.05).In 738 patients with isolated systolic hypertension,the control rate was 35.6%.Conclusion Hydrochlorothiazide had a good effect for treating the rural patients with primary hypertension.Hydrochlorothiazide should be the first choice.