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大蒜油β-环糊精包合物的稳定性考察
引用本文:何进,毕殿洲.大蒜油β-环糊精包合物的稳定性考察[J].中国药学杂志,1997,32(4):216-218.
作者姓名:何进  毕殿洲
作者单位:沈阳军区总医院康乐制药厂,沈阳药科大学,沈阳军区总医院药剂科
摘    要: 目的:考察大蒜油β-CD包合物的稳定性。方法:以大蒜油为测定指标,分别对包合物和混合物进行强光照射、高温、高湿、挥发性试验及恒温加速实验。结果:在光、热、湿等因素影响下,包合物中大蒜油含量没有明显变 化,而混合物中大蒜油含量均明显下降,说明大蒜油包合后增加了对光、热、湿的稳定性;挥发性试验结果,包合物的热失重比混合物小,说明包合物降低了大蒜油的挥发性。结论:大蒜油β-CD包合物具有一定的杭光照性、热稳定性和湿稳定性,其稳定性明显优于单纯大蒜油。

关 键 词:大蒜油  β-环糊精  稳定性
收稿时间:1996-03-25;

The stabilities of inclusion complex of garlic oil-β-cyelodextrin
He Jin.The stabilities of inclusion complex of garlic oil-β-cyelodextrin[J].Chinese Pharmaceutical Journal,1997,32(4):216-218.
Authors:He Jin
Institution:(He J),Bi Dianzhou(Bi DZ),Liu Baoqing(Liu BQ),et u
Abstract:OBJECTIVE: To observe the stabilities of inclusion complex of garlic oil-β-cyclodextrin(β-CD).METHODS: We used garlic oil as a index and made a set of tests of inclusion complex and mixture on their stabilities,such as tests under lamp light and under high temperature or humidity, volatility test and constant-temperature accelerated test. RESULTS: Under affecting factors such as light, heat and humidity, the content of garlic oil in inclusion complex was not changed. In the mixture, however, the content of garlic oil was decreased. It was shown that garlic oil in inclusion complex was much more stable under light, heat and humidity. In the volatility test, hot weightless of the complex was smaller than that of the mixture, indicating that inclusion complex was able to lower volatilization of garlic oil. CONCLUSION: Inclusion complex of garlic oil-β-CD had the stabilities to light, heat and humidity to some extent. The stability of garlic oil in inclusion complex was obviously superior to that of original garlic oil.
Keywords:garlic oil  β-CD  stability
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