| The glucocorticoid resistance in burn and shock |
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| 作者姓名： | 徐仁宝 |
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| 作者单位： | Department of |
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| 摘 要： | The changes of glucocorticoid receptor (GR) and the reactivity of target cells toglucocorticoids (GC) were studied experimentally.The results showed that GC resistance,which wascaused mainly by the decrease of GR,developed in burned and shocked rats and dogs.Thesechanges may exacerbate the shock state,and even lead to the development of multiple organfailuue.The protection of GC against intestinal ischemic shock of dogs was demonstrated after theconcentration of dexamethasone (Dex) in plasma was elevated to 10~(-6) mol/L by iv injection of 5mgDex/kg body weight.
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The glucocorticoid resistance in burn and shock |
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| Xu Renbao.The glucocorticoid resistance in burn and shock[J].Journal of Medical Colleges of PLA(China),1991(4). |
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| Authors: | Xu Renbao |
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| Institution: | Xu Renbao Department of Pathophysiology,Second Military Medical University,Shanghai 200433 |
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| Abstract: | The changes of glucocorticoid receptor (GR) and the reactivity of target cells to glucocorticoids (GC) were studied experimentally.The results showed that GC resistance,which was caused mainly by the decrease of GR,developed in burned and shocked rats and dogs.These changes may exacerbate the shock state,and even lead to the development of multiple organ failuue.The protection of GC against intestinal ischemic shock of dogs was demonstrated after the concentration of dexamethasone (Dex) in plasma was elevated to 10~(-6) mol/L by iv injection of 5mg Dex/kg body weight. |
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| Keywords: | glucocorticoid resistance glucocorticoid receptor hurns shock treatment |
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