CysC和Hcy在糖尿病肾病中的应用

目的探讨胱抑素C（CysC）和同型半胱氨酸（Hcy）联合检测在糖尿病肾病（DN）中的临床应用价值。方法根据24尿白蛋白排泄率将142例糖尿病（DM）患者分为单纯糖尿病组（SDM组）、早期糖尿病肾病组（EDN组）、临床糖尿病肾病组（CDN组）,分别检测各组患者血清中CysC和Hcy。结果 CysC浓度在4组之间经方差分析,其差异具有统计学意义（F=180.273,P〈0.05）;Hcy浓度在4组之间经方差分析,其差异具有统计学意义（F=117.064,P〈0.05）。CysC和Hcy的浓度在SDM组与正常对照组（NC组）之间进行两两比较时,经统计学分析其差异无统计学意义（P〉0.05）;而EDN组和CDN组分别与NC组进行两两比较时,经统计学分析其差异均有统计学意义（P〈0.05）;CysC和Hcy在SDM、EDN、CDN 3组间的浓度呈逐渐增高趋势,且3组之间进行两两比较时,经统计学分析,其差异均有统计学意义（P〈0.05）。结论 CysC和Hcy联合检测可作为DN的早期诊断指标,同时也可作为DN病情的监测指标。

Clinical application of CysC and Hcy detection in diabetic nephropathy

Abstract： Objective To study the value of clinical application of detection of serum cystatin C（Cysc）, hemocysteine（Hcy） in judgement of renal damage of patients with early diabetic nephropathy（DN）. Methods According to 24 h urinary albumin excretion rate（UAER）, 142 patients with diabetes mellitus（DM） were divided into three groups, including simple diabetes mellitus（SDM）, early diabetic nephropathy（EDN） and clinical diabetic nephropathy（CDN） group. Results There were significant differences among the four groups considering the concentration of CysC and Hcy（F=180.273, P〈0.05. F=117.064, P〈0.05）. There were no significant differences between SDM and NC groups connecting the concentration of CysC and Hcy（P〉0.05）. There were significant differences between EDN, CDN and NC groups connecting the concentration of CysC and Hey（P〈0.05）. There was an increased trend in the concentration of CysC and Hey in the groups of SDM, EDN and CDN. There were significant differences between the groups （P〈0.05）. Conclusion The combined detection of CysC and Hey were sensitve indicators in judgement of early renal damage of DN patients, At the same time, they could be used as a monitoring index in patients with DN.