咪唑斯汀联合玉屏风散治疗慢性荨麻疹的疗效观察

目的观察咪唑斯汀联合中药玉屏风散治疗慢性荨麻疹的临床疗效及安全性。方法将120例慢性荨麻疹患者采用随机数字表分组法分为2组，试验组62例口服咪唑斯汀10mg／d，联合玉屏风散1剂/天，分2次口服；对照组58例，口服咪唑斯汀，用法、用量同试验组。2组均连续用药治疗4周，并分别在1周、2周、4周依据治疗前、后患者的临床症状、体征下降指数进行疗效评估。结果试验组有效率为91．93％，对照组为70．69％，2组比较差异有统计学意义（P〈O0．01）。结论咪唑斯汀联合玉屏风治疗慢性荨麻疹疗效好，毒副作用小，治愈率高，复发率低。

Clinical observation on curative effect of mizolastine combined with Yupingfengsan in the treatment of chronic urticaria

Objective To observe the clinical curative effects and security ofmizolastine combined with traditional Chinese medicine（Yupingfengsan） in the treatment of chronic urticaria. Methods 120 patients of chronic urticaria were divided into 2 groups randomly. The experimental group had 62 patients while the control group had 58 patients. The patients in experimental group took mizolastine 10 mg/d and Yupingfengsan 1 dose/d twice a day. The control group took mizolastine 10mg/d only. The two groups were treated continuously for four weeks together. The clinical curative effects were appraised according to the clinical symptoms and physical decline index before and after the treatment at 1st, 2nd week and 4th week. Results The effective rates were 91.93% and 70.69% respectively in the experimental group and the controls. There was a significant difference between the two groups（P〈0.01）. Conclusion Mizolastine combined with traditional Chinese medicine（Yupingfensan） is quite effective in the treatment of chronic urticaria, with less side effects, high cure rate and low recurrence.