肌苷、维生素B6联合羚羊角颗粒治疗儿童抽动障碍的对照研究

目的：比较肌苷、维生素B6联合羚羊角颗粒（简称肌苷疗法）与氟哌啶醇治疗儿童抽动障碍的疗效及安全性 方法：对愿意接受药物治疗的88例抽动障碍患儿按照随机化原则分为研究组和对照组,研究组应用肌苷疗法,对照组应用氟哌啶醇治疗,共治疗8周,在治疗前后采用耶鲁抽动症状严重程度量表（YGTSS）评定疗效,并应用副反应量表（TESS）评定氟哌啶醇不良反应,同时观察肌苷疗法有无不良反应 结果：在第8周末,研究组和对照组的治疗有效率无显著性差异（P＞0.05）,两组总有效率接近,研究组的不良反应显著少于对照组（P＜0.05） 结论：肌苷疗法能有效治疗儿童抽动障碍,且肌苷疗法副作用少,安全性好,依从性好.

A Control Study of Combination of Inosine, Vitamin B6 and Lingyangjiao in the Treatment of Childhood Tic Disorder

Objective：To evaluate the efficacy and side effects of the combination of Inosine,vitamin B6 and Lingyangjiao （abbr.inosine treatment） vs.haloperidol in the treatment of childhood tic disorder.Methods：A total of 88 cases of childhood tic disorder were treated with either inosine treatment （n=44） or haloperidol （n=44）.The two groups were followed for 8 weeks,the efficacy of inosine treatment and haloperidol were evaluated by Yale Global Tie Severityb Scale （YGTSS）.The side effects of haloperidol were evaluated by TESS.Results：The effective rates had no significant differences between the two groups in the 8th weekend （P＞0.05）.The side effects were significantly less in the inosine treatment group than those in the haloperidol group （P＜0.05）.Conclusion：Inosine treatment is as effective as haloperidol for childhood tic disorder with higher compliance.