Lipid peroxidation in fatty liver induced by caffeine in rats. |
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| Authors: | M U Dianzani G Muzio M E Biocca R A Canuto |
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| Institution: | Department of Medicine and Experimental Oncology, University of Turin, Italy. |
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| Abstract: | An increase in lipid peroxidation has been found in liver after poisoning with hepatotoxic substances and following dietary changes, i.e. choline-devoid diet and orotic acid-rich diet. In this study we analysed in the rat a model of fatty liver induced by administration of caffeine. The results seem to indicate an increased peroxidability in the liver of caffeine-treated animals, due to an increase in triglyceride content. A decrease of vitamin E which also occurs might contribute to the lipid peroxidation. |
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