中链脂肪酸对营养性肥胖大鼠体重及脂质代谢的作用

目的研究中链脂肪酸(MCFA)对营养性肥胖大鼠体重、体脂和血脂水平的影响。方法采用预防肥胖模型法,每天给予SD大鼠高脂营养饲料,并灌胃含不同剂量MCFA的食用油脂,饲养38天,观察体重、摄食量、体脂重量、血脂、胰岛素水平在不同剂量组动物间的差异。结果高、中、低三个剂量组大鼠分别摄入0·975、0·325和0·163g/kg bw MCFA38天,高剂量组与模型对照组相比,体重明显较低分别(295·2±29·7)g和(324·6±9·1)g](P<0·05),脂肪垫重量明显较轻分别(5·30±1·57)g和(7·20±1·74)g](P<0·05),脂肪细胞明显较小;各剂量组总的摄食量不显著低于模型对照组;血清甘油三酯(TG)、总胆固醇(TC)、胰岛素水平与模型对照组比较差异无显著性,中、高剂量组高密度脂蛋白胆固醇(HDL-C)水平高于模型对照组分别(0·71±0·11)mmol/L、(0·73±0·12)mmol/L、(0·60±0·06)mmol/L](P<0·05),高剂量组大鼠的瘦素水平显著低于模型对照组分别(1·61±0·39)ng/ml和(2·04±0·46)ng/ml](P<0·05)。结论在饲料摄入量没有差别的前提下,摄入0·975g/kg bw MCFA对营养性肥胖大鼠的体重增长有一定抑制作用,对血脂水平没有不良影响。

Effects of medium-chain fatty acid on weight gain and lipids metabolism in obese rats

OBJECTIVE: Some researchers considered medium chain fatty acids a group of potential agents in the prevention of obesity for their particular metabolism characters. METHODS: In this study, the authors investigated the effects of medium chain fatty acids on body weight gains, food intake, adipose depots and serum lipid profiles. Healthy male Sprague-Dawley rats were fed for 38 days with over-fat diets and oils containing MCFA at different level. RESULTS: Significant decreases of body weight ( 295.2 +/- 29.7) g vs. (324.6 +/- 9.1) g] (P < 0.05), the weight of adipose pads (5.30 +/- 1.57) g vs. (7.20 +/- 1.74) g](P < 0.05), the level of leptin in serum(1.61 +/- 0.39) ng/ml vs. (2.04 +/- 0.46) ng/ml] (P < 0.05), the sizes of fat cells but increase of HDL-C (0.73 +/- 0.12) mmol/L vs. (0.60 +/- 0.06)mmol/L] (P < 0.05) were noted in the group fed MCFA at 0.975 g/kg bw per day as compared with those of the group fed soybean oil. CONCLUSION: The results suggested the role of MCFA in prevention of obesity and there is no adverse effect on lipid metabolism if the proportion of MCFA to total fat scouce is mild.