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| 三联脆组基因在外阴癌和外阴尖锐湿疣中的表达 | |
| 引用本文： | 范余娟,杨开选,龙凤宜,刘辉,徐红.三联脆组基因在外阴癌和外阴尖锐湿疣中的表达[J].现代预防医学,2006,33(11):2055-2056. |
| 作者姓名： | 范余娟 杨开选 龙凤宜 刘辉 徐红 |
| 作者单位： | 1. 广西医科大学附一妇产科,南宁,530021 2. 四川大学华西第二医院病理科 3. 四川大学华西第二医院妇产科 |
| 摘 要： | 目的：探讨三联脆组（FHIT）基因在外阴癌和外阴尖锐湿疣中的表达及其意义.方法：应用免疫组化SP法检测30例外阴鳞癌、30例外阴尖锐湿疠、15例正常外阴皮肤组织中FHIT蛋白的表达情况.结果：FHIT蛋白在正常外阴上皮、外阴尖锐湿疣、外阴鳞癌中的阳性表达率分别为100%.（15/15）、53.33%（16/30）和20%（6/30）,外阴尖锐湿疣和外阴鳞癌中FHIT蛋白的阳性表达率较正常外阴上皮明显降低（P＜0.05）,外阴鳞癌中FHIT蛋白的低表达与外阴癌的组织分化和临床分期均无关系（P＞0.05）.结论：1.FHIT基因异常表达与外阴鳞癌的发生发展有关.2.外阴尖锐湿疣可能是外阴鳞癌的前期病变. |
| 关 键 词： | 三联脆组 基因 外阴癌 尖锐湿疣 表达 |
| 文章编号： | 1003-8507（2006）11-2055-02 |
| 收稿时间： | 2005-07-11 |
| 修稿时间： | 2005年7月11日 |
FRAGILE HISTIDINE TRIAD EXPRESSION IN VULVAR CANCER AND VULVAR CONDYLOMA ACUMINATUM |
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| FAN Yu-juan,YANG Kai-xuan, LONG Feng-yi,et al..FRAGILE HISTIDINE TRIAD EXPRESSION IN VULVAR CANCER AND VULVAR CONDYLOMA ACUMINATUM[J].Modern Preventive Medicine,2006,33(11):2055-2056. | |
| Authors: | FAN Yu-juan YANG Kai-xuan LONG Feng-yi |
| Institution: | Department of Gynecology , The First Affliated Hospital of Guangxi Medical University, Nannig , 530021 |
| Abstract: | Objective:To study the expression of Fragile histidine triad(FHIT)protein in vulvar cancer and vulvar condyloma acuminatum.Method:Immunohistochemistry was used to detect the expression of FHIT in 15 cases of normal vulvar epithelium,30 cases of vulvar condyloma acuminatum and 30 cases of vulvar cancer.Resuts:The expression rate of FHIT protein were 100%(15/15)in normal vulvae,53.33%(16/30)in condyloma acuminatum of vulva and 20.00%(6/30)in vulvar cancers.The expression rate of FHIT in vulvar vulvae(P<0.05).The FHIT expression was not correlated with the histological grade and the clinical stage of vulvar cancer(P>0.05).Conclusion:The abnormal expression of FHIT protein may play an important role in the development and progression of vulvar cancer.Vulvar condyloma acuminata may be a precancerous stage of vulvar cancer. |
| Keywords: | Fragile Histidine Gene Vulvar cancer Condyloma acuminaturn Expression |
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