C反应蛋白自身抗体与急性冠脉综合征斑块不稳定的相关性研究

目的:探讨C反应蛋白(CRP)自身抗体与急性冠脉综合征(ACS)患者冠脉病变严重程度、斑块不稳定的相关性.方法:应用间接酶联免疫吸附法检测120例ACS,61例稳定型心绞痛(SAP)和120例对照者血清CRP自身抗体吸光度(A)值,并以对照组的95%可信区间A值作为判断CRP自身抗体阳性或阴性的界点.结果:ACS征组血浆CRP自身抗体A值水平(1.75±1.09)显著高于SAP(1.27±0.61)和对照组(0.88±0.43),P<0.001,并与冠状动脉病变积分无相关性(P>0.05).ACS组CRP自身抗体阳性比例(44.17%)显著高于SAP组(8.84%),P<0.001.结论:CRP自身抗体不是反映ACS患者冠状动脉病变严重程度的指标,CRP自身抗体水平可能是随着斑块不稳定而变化的,与ACS患者斑块不稳定相关,但CRP自身抗体在ACS中的作用机制尚不明了.

A preliminary study between serum anti-CRP autoantibodies and plaque unstable in acute coronary syndrome

Objective:To investigate the changes of serum anti-CRP autoantibodies(CRP-Ab) and their relationship in acute coronary syndrome (ACS) patients. Methods:Serum samples were taken from all patients with ACS(n=120),stable angina pain (SAP)(n=61) and subjects without coronary heart disease (NCAD) (n=120)subjects. The serum levels of CRP-Ab(IgG)were quantitatively measured by indirect ELISA assay. Absorbance(A) was measured at 405 nm. Positive cut-off values were calculated from the 95 th percentile of the A valu...