| 广东人汉族群CTLA-4基因外显子1多态性与Graves病的相关性 |
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| 引用本文： | 余绮玲,陈定宇,肖正华,王燕. 广东人汉族群CTLA-4基因外显子1多态性与Graves病的相关性[J]. 解剖学研究, 2006, 28(4): 278-280 |
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| 作者姓名： | 余绮玲 陈定宇 肖正华 王燕 |
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| 作者单位： | 广州市第一人民医院内分泌科,广东,广州,510180;广州市第一人民医院内分泌科,广东,广州,510180;广州市第一人民医院内分泌科,广东,广州,510180;广州市第一人民医院内分泌科,广东,广州,510180 |
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| 摘 要： | 目的探讨CTLA-4基因外显子1多态性与广东地区汉族人群Graves病的关系。方法以PCR-RFLP技术观察100名健康人与100例Graves病(GD)患者细胞毒性T淋巴细胞相关抗原4(CTLA-4)基因外显子1的多态性。结果提示GD患者的CTLA-4外显子1的G49等位基因频率较正常对照组显著增高(P<0.01)。结论CTLA-4基因可能是广东地区汉族人群中GD的易感候选基因。
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| 关 键 词： | 细胞毒性T淋巴细胞相关抗原4基因 Graves病 基因多态性 汉族 |
| 收稿时间： | 2006-05-10 |
| 修稿时间： | 2006-05-10 |
Association of polymorphism of CTLA-4 gene exon 1 with Graves disease in Cantonese Han population |
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| YU Qi-ling,CHEN Ding-yu,XIAO Zheng-hua,WANG Yan. Association of polymorphism of CTLA-4 gene exon 1 with Graves disease in Cantonese Han population[J]. Anatomy Research, 2006, 28(4): 278-280 |
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| Authors: | YU Qi-ling CHEN Ding-yu XIAO Zheng-hua WANG Yan |
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| Abstract: | Objective To investigate the association of gene polymorphism of cytotoxic T lymphocyte,associated antigen,4 (CTLA,4) with Graves disease (GD) in Cantonese Han population. Methods The poly,morphism of cytotoxic T lymphocyte associated antigen,4 (CTLA,4) was investigated by PCR,RFLP in 100 healthy volunteers and 100 patients with GD. Results The frequency of G49 allele of CTLA,4 exon 1 in GD patients was significantly higher than that in normal controls (P<0.01). Conclusion CTLA,4 gene seems to be a new susceptible candidate gene of GD in Cantonese Han population. |
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| Keywords: | Cytotoxic T lymphocyte associated antigen 4 gene Graves disease Gene polymorphism Han population |
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