| 血小板生成素的研究进展 |
| |
| 引用本文： | 陈建魁 牟兆钦. 血小板生成素的研究进展[J]. 军事医学科学院院刊, 1995, 19(4): 303-306 |
| |
| 作者姓名： | 陈建魁 牟兆钦 |
| |
| 作者单位： | 北京军事医学科学院附属医院 |
| |
| 摘 要： | 根据近年来的文献报道，概述了血小板生成素（ＴＰＯ）的研究进展。人ＴＰＯ基因长度约为６．２ｋｂ，含有６个外显子和个内含子。所有外显子－内含子的连接符合ＧＴ／ＡＧ规则。其ｃＤＮＡ克隆由１７７４个核苷酸附加一个多聚腺苷酸尾巴构成，它是一个１０５９个核苷酸的可译框架，是一种单拷贝基因。转录起始位点位于其ＤＮＡ－１９４９位的胞嘧啶外，在转录起始位占上游１．４ｋｂ的序列中没有通常哺乳动物启动子的基序和ＴＡＴＡ
|
| 关 键 词： | 血小板生成素 血小板 巨核细胞 细胞因子 |
Advances in the research of thrombopoietin |
| |
| Chen Jiankui,Mu Zhaoqin,Huang Shimin. Advances in the research of thrombopoietin[J]. Bulletin of the Academy of Military Medical Sciences, 1995, 19(4): 303-306 |
| |
| Authors: | Chen Jiankui Mu Zhaoqin Huang Shimin |
| |
| Abstract: | Thrombopoietin(TPO) is a cytokine which involved in the regulation of platelet production. It has re-cently been purified and cloned. In this paper, the structure of genomic DNA, chromosome mapping, the proteinstructure, biological functions and prospect of clinical application of TPO are reviewed. |
| |
| Keywords: | thrombopoietin blood plateletes megakaryocytes cytokine |
| 本文献已被 CNKI 维普 等数据库收录！ |
