| 阿魏酸对血管性痴呆大鼠学习记忆障碍的改善作用及其机制研究 |
| |
| 引用本文： | Luo Y,Zhao HP,Zhang J,Wang J,Yang WL,Yang M,Liao ZG. 阿魏酸对血管性痴呆大鼠学习记忆障碍的改善作用及其机制研究[J]. 药学学报, 2012, 47(2): 256-260 |
| |
| 作者姓名： | Luo Y Zhao HP Zhang J Wang J Yang WL Yang M Liao ZG |
| |
| 作者单位： | (江西中医学院现代中药制剂教育部重点实验室, 江西 南昌 330004) |
| |
| 基金项目： | 国家“重大新药创制”科技重大专项(2009ZX09310-005) |
| |
| 摘 要： | 血管性痴呆(vascular dementia,VD)是一种严重威胁老年人生命健康的神经退行性疾病,随着人口的老龄化,VD发病率逐年上升,寻找安全有效的抗VD药物已成为药物研究的热点[1,2]。近年来,中医药以活血化瘀法治疗VD取得了较大进展[3?5]。川芎是一种典型的活血化瘀中药,始载于《神农本草经》,具有活血行气、祛风止痛的功效,广泛用于VD
|
| 关 键 词： | 阿魏酸 血管性痴呆 乙酰胆碱酯酶 兴奋性氨基酸 抗氧化作用 |
Effect of ferulic acid on learning and memory impairments of vascular dementia rats and its mechanism of action |
| |
| Luo Yun,Zhao Hai-Ping,Zhang Jing,Wang Jie,Yang Wu-Liang,Yang Ming,Liao Zheng-Gen. Effect of ferulic acid on learning and memory impairments of vascular dementia rats and its mechanism of action[J]. Acta pharmaceutica Sinica, 2012, 47(2): 256-260 |
| |
| Authors: | Luo Yun Zhao Hai-Ping Zhang Jing Wang Jie Yang Wu-Liang Yang Ming Liao Zheng-Gen |
| |
| Affiliation: | Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. |
| |
| Abstract: | This study is to investigate the effect of ferulic acid on learning and memory impairments of vascular dementia (VD) rats and its mechanism of action. VD rats model was replicated by permanent bilateral common carotid artery occlusion (2VO). The learning and memory capability of VD rats was evaluated by Morris water maze. The activity of acetylcholinesterase (AChE) and superoxide dismutase (SOD) and the content of glutamic acid (Glu) and malondialdehyde (MDA) in hippocampus of VD rats’ brain were determined, separately. The results showed that ferulic acid could alleviate learning and memory deficits of VD rats significantly. Ferulic acid was found to inhibit the activity of AChE and increased the activity of SOD in rat hippocampus. In addition, ferulic acid could also decrease the content of Glu and MDA in rat hippocampus. These results suggested that ferulic acid could alleviate VD rats’ learning and memory deficits, which might be due to antioxidation, the improvement of cholinergic system in brain, or the inhibitory of nerve injury by excitatory amino acids. |
| |
| Keywords: | ferulic acid vascular dementia acetylcholinesterase excitatory amino acid antioxidation |
| 本文献已被 CNKI PubMed 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
|
