托吡卡胺所致的睫状肌麻痹对儿童眼前节参数的影响

目的 研究0.5%托吡卡胺滴眼液所致的睫状肌麻痹前后儿童眼前节参数的变化。方法 选择309名健康儿童，0.5%托吡卡胺滴眼液滴眼麻痹睫状肌，睫状肌麻痹前后分别采用Pentacam系统测量眼前节参数。分析睫状肌麻痹前后眼前节参数的变化以及不同屈光状态和不同性别儿童睫状肌麻痹前后眼前节参数的变化。结果 294名儿童的检查结果符合纳入标准。睫状肌麻痹后，中央角膜厚度（CCT）、角膜容积（CV）、前房深度（ACD）和前房容量（ACV）显著大于睫状肌麻痹前（P<0.05或P<0.01），前房角(ACA)显著小于睫状肌麻痹前(P<0.05)。远视者睫状肌麻痹前后ACD差值显著大于正视者、低度近视者和中度近视者 (P<0.05)，远视者睫状肌麻痹前后ACV差值显著大于低度近视者和中度近视者（P<0.001）。男孩睫状肌麻痹后ACA显著小于睫状肌麻痹前（P<0.05），女孩睫状肌麻痹前后ACA差异无统计学意义（P>0.05）。结论 0.5%托吡卡胺滴眼液可导致儿童CCT、CV、ACD和ACV显著增加，ACA显著减小。

Effect of cycloplegia induced by tropicamide on ocular anterior segment parameters in children

Objective To investigate the changes of ocular anterior segment parameters before and after cycloplegia induced by 0.5% tropicamide in children. Methods Three hundred and nine healthy children were selected, cycloplegia was induced by 0.5% tropicamide, and ocular anterior segment parameters were measured with Pentacam system before and after cycloplegia. The changes of ocular anterior segment parameters before and after cycloplegia were investigated, and those stratified by refractive status and genders were analysed. Results The data of 294 children met the inclusion criteria. The central corneal thickness (CCT), corneal volume (CV), anterior chamber depth (ACD) and anterior chamber volume (ACV) after cycloplegia were significantly larger than those before cycloplegia (P<0.05 or P<0.01), and the anterior chamber angle (ACA) after cycloplegia was significantly smaller than that before cycloplegia (P<0.05). The difference between ACD after cycloplegia and that before cycloplegia in children with hyperopia was significantly larger than those in children with emmetropia, low myopia and medium myopia (P<0.05), and the difference between ACV after cycloplegia and that before cycloplegia in children with hyperopia was significantly larger than those in children with low myopia and medium myopia (P<0.001). ACA after cycloplegia was significantly smaller than that before cycloplegia in boys (P<0.05), while ACA after cycloplegia was not different from that before cycloplegia in girls (P>0.05). Conclusion 0.5% tropicamide may cause significant increase in CCT, CV, ACD and ACV, and significant decrease in ACA in children.