The trypanocidal effect of drugs in different parts of the brain |
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| Authors: | B H Raseroka W E Ormerod |
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| Affiliation: | 1. State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, 200031, Shanghai, China;2. Molecular Biology Laboratory, School of Biotechnical, Biosecurity and Laboratory Sciences, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P. O. Box 7062, Kampala, Uganda;3. Centre for Parasitic Organisms, School of Life Sciences, Sun Yat-Sen University, Guangzhou, 510276, China;1. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1990-375 Lisboa, Portugal;2. Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA;3. Graduate Program in Areas of Basic and Applied Biology, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4099-002 Porto, Portugal;4. Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA;5. Department of Biomedical Sciences, Unit of Veterinary Protozoology, Institute of Tropical Medicine Antwerp, B-2000 Antwerp, Belgium;6. Department of Physiology, Laboratory of Zoophysiology, University of Ghent, B-9000 Ghent, Belgium;7. Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK;8. Guest Professor, Faculdade de Medicina, Universidade de Lisboa, 1990-375 Lisboa, Portugal;1. Interfaculty Institute of Biochemistry, University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany;2. Institute of Pathology and Neuropathology, University of Tübingen, Liebermeisterstr. 8 72076 Tübingen, Germany |
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| Abstract: | Three parts of the brain, cerebral cortex, lining of ventricle and choroid plexus, are cleared of trypanosomes to different extents by different drugs. There appear to be several barriers preventing drugs from acting in different parts of the brain, the concept of a single "blood-brain barrier" does not account for the phenomena observed. The protection of trypanosomes from certain drugs by the choroid plexus and ventricular wall supports the concept of an intracellular stage of Trypanosoma brucei in the ependymal cell; this concept is also supported by differences in parasitaemia resulting from the inoculation of ependymal and of other tissues. Alternative therapies for sleeping sickness are suggested, one of which (suramin/metronidazole) is being advanced for trials in man. |
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