| 山楂叶总黄酮对高脂血症大鼠血清SOD、MDA及PON1的影响 |
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| 引用本文： | 杨宇杰,陈建双,王春民,党晓伟.山楂叶总黄酮对高脂血症大鼠血清SOD、MDA及PON1的影响[J].中国医院药学杂志,2010(3). |
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| 作者姓名： | 杨宇杰 陈建双 王春民 党晓伟 |
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| 作者单位： | 承德医学院;承德颈复康药业集团有限公司; |
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| 摘 要： | 目的:探讨山楂叶总黄酮(hawthorn leaves flavonoids,HLF)对高脂血症大鼠抗氧化作用的影响及与PON1活性的关系。方法:采用维生素D3加脂肪乳剂造成大鼠高脂血症模型,并检测血清超氧化物歧化酶(SOD)、丙二醛(MDA)及对氧磷酶(PON1)含量。结果:1.HLF可明显降低血清总胆固醇(TC)、甘油三脂(TG)和低密度脂蛋白胆固醇(LDL-C)含量,提高高密度脂蛋白胆固醇(HDL-C)/TC比值。2.HLF可增强SOD及PON1活性,抑制高脂饮食所升高的MDA水平。结论:HLF具有较强的抗氧化作用,其抗AS作用可能与其增加PON1表达、继而增强HDL抗氧化能力有关。
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| 关 键 词： | 山楂叶总黄酮 高脂血症 对氧磷酶 抗氧化 |
Protective effects of hawthorn leaves flavonoids against vascular disfunction of hyperlipidemia rats |
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| YANG Yu-jie,CHEN Jian-shuang,WANG Chun-min,DANG Xiao-wei.Protective effects of hawthorn leaves flavonoids against vascular disfunction of hyperlipidemia rats[J].Chinese Journal of Hospital Pharmacy,2010(3). |
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| Authors: | YANG Yu-jie CHEN Jian-shuang WANG Chun-min DANG Xiao-wei |
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| Institution: | YANG Yu-jie1,CHEN Jian-shuang1,WANG Chun-min2,DANG Xiao-wei2 (1.Chengde Medical College,Hebei Chengde 067000,China,2.Chengde JFK Pharmaceutic Group CO.,Ltd,China) |
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| Abstract: | OBJECTIVE To study the antioxidant effect and possible mechanisms related to serum paraoxonase 1(PON1) activity of Hawthorn leaves flavonoids in hyperlipidemia rats.METHODS Using fat emulsion plus vitamin D3 to set up the hyperlipidemia model,determining the content of SOD,MDA and PON1 in blood serum.RESULTS HLF could obviously decrease the contents of cholesterol(TC),triglyceride(TG) and LDL-C in blood serum,and increase the ratio of high density lipoprotein to total cholesterol.HLF could improve the serum... |
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| Keywords: | hawthorn leaves flavonoids hyperlipidemia paraoxonase 1 antioxidant |
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