胃镜下注射去甲肾上腺素联合常规三联疗法治疗消化性溃疡并消化道出血疗效观察

目的观察胃镜下注射去甲肾上腺素联合奥美拉唑、克拉霉素及甲硝唑等三联疗法治疗消化性溃疡并消化道出血的临床疗效及安全性。方法在知情同意情况下，84例消化性溃疡并消化道出血患者按数字表法随机分为观察组和对照组各42例，对照组予奥美拉唑、克拉霉素及甲硝唑等三联疗法，配合常规止血药物治疗；观察组在对照组的基础上在胃镜下于胃黏膜出血点处注射去甲。肾上腺素治疗，观察两组治疗总有效率及不良反应发生情况。结果观察组显效36例、有效5例、无效1例、总有效率97．6％，对照组分别为21例、16例、5例、88．1％，两组总有效率差异有统计学意义（X^2=5．137，P〈0．05），两组均未发生严重不良反应。结论胃镜下注射去甲。肾上腺素联合常规三联疗法治疗消化性溃疡并消化道出血疗效显著，不良反应。

The clinical effect of gastroscopy injection of norepinephrine combined with routine triple therapy on peptic ulcer patients with gastrointestinal bleeding

Objective To observe the effect of gastroscopy injection of norepinephrine combined with routine triple therapy on peptic ulcer with gastrointestinal bleeding. Methods 84 cases of gastroscopy upper gastrointestinal bleeding caused by peptic ulcer patients were randomly divided into two groups, the control group 42 cases;the observation group 42 cases, the observation group was guven endoscopic injection of norepinephrine combined conventional triple therapy,the control group was given conventional triple therapy with hemostatic therapy. Efficiency and adverse reactions were observed in patients. Results In the observation group,36 csses was significantly effective,5 cases was effective,1 case was not effective,the total effective rate was 97.6%. In the control group,21 cases was significantly effective, 16 cases was effective ,5 cases was not effective,the total effective rate was 88. 1% ,the difference of the total effective rate between the two groups was significant( x2 =5. 137, P ＜ 0. 05 ). There was no serious adverse reactions in the two groups. Conclusion Endoscopic injection of norepinephrine and routine triple therapy in treatment of gastrointestinal hemorrhage of peptic ulcer was significantly better than conventional medical treatment alone.