C反应蛋白检测对溃疡性结肠炎活动性的评价

目的探讨12反应蛋白（CRP）检测对溃疡性结肠炎活动性的评估价值。方法分析41例活动期和17例缓解期溃疡性结肠炎患者血清CRP，比较临床病情程度对CRP的影响。结果活动性UC患者的血清CRP水平为（8．58±2．43）mg／L，其中重度UC患者CRP水平为（14．38±4．46）mg／L，中度UC患者CRP水平为（6．68±2．35）mg／L，轻度UC患者CRP水平为（4．94±1．21）mg／L，而缓解期UC患者CRP水平为（3．05±0．88）mg／L。活动期溃疡性结肠炎患者血清CRP表达率明显高于缓解期患者，差异有统计学意义（x^2=18．72，P〈0．05）；重型溃疡性结肠炎患者血清CRP表达率高于中型溃疡性结肠炎患者，差异有统计学意义（P〈0．05）；中型溃疡性结肠炎患者血清CRP表达率亦高于轻型溃疡性结肠炎患者，差异有统计学意义（x^2=8．16，P〈0．05）。结论CRP水平升高能反映活动期溃疡性结肠炎患者临床病情严重程度，为临床诊治提供重要理论依据。

The evaluation of C-reactive protein on the activity of ulcerative Colitis

Objective To determine the role of C-reactive protein(CRP) in evaluating the activity of ulcerative colitis. Methods Analysis was used to estimate the correlation of CRP with mean platelet volume in 41 patients with active ulcerative colitis and 17 patients ulcerative colitis in re-mission. The effects on disease severity were analyzed subsequently. Results Active UC patients sera CRP level(8.58 ±2.43)mg/L,which level of severe UC CRP (14.38 ±4.46)mg/L,the moderate level of CRP UC(6.68 ±2.35)mg/L,mild level of CRP UC(4.94 ±1.21)mg/L, while the remission stage UC patients CRP levels(3.05 ±0. 88)mg/L. CRP was found to be significantly higher in sera of patients with active ulcerative colitis than that in patients in remission (P ＜ 0.05). The sera level of CRP in inflammatory bowel disease at severe stage were significantly higher than those of medium stage (P ＜ 0. 05). CRP was observed to be slightly increased in sera of patients at mild stage (P ＜ 0. 05). Conclusion The increase of CRP could reflect the severity of active ulcerative colitis.