尼可地尔治疗心绞痛80例临床观察

目的观察尼可地尔治疗心绞痛的疗效。方法将155例心绞痛患者随机分为治疗组（85例）和对照组（70例），两组均常规服用阿司匹林0．1g/d，氯吡格雷50mg／d，单硝酸异山梨酯50mg／d，辛伐他汀40mg／d，有高血压或糖尿病者别予控制血压及血糖，有心衰者予适当利尿等减轻心脏负荷，治疗组在常规基础上加用尼可地尔5mg，3次／d，1个月为一疗程。两组均治疗1个疗程。结果治疗组显效32例，有效34例，无效14例，总有效率为82．5％；对照组显效23例，有效28例，无效24例，总有效率为67．0％。两组总有效差异有统计学意义（χ^2=4．40，P〈0．05）。两组除有少数患者出现轻度头晕外，未见其它明显不良反应。结论尼可地尔治疗心绞痛疗效好，无明显不良反应。

Clinical observation of nicorandil in treatment of 85 patients with angina pectoris

Objective To observe the therapeutic effect of nicorandil in treatment of angina pectoris. Methods 155 cases of angina pectoris patients were randomly divided into the therapeutic group(85 cases)and control group(70 cases),both of which took normal doses of aspirin vitamin C effervescent tablets 0.1g/day,clopidogrel 50mg/day,elantan 50mg/day and simvastatin 40mg/day,where hypertensions or diabetics were given blood pressure and sugar control and heart failure patients were given proper diuretic therapy and other methods to release heart Ioad.Patients in the therapeutic group were additionally given 5 mg nicorandil,3 times/day.The two groups were both given one period of treatment about one month. Results In therapeutic group,32 cases had significant therapeutic effectiveness,34 cases had effectiveness and 14 cases had no effectiveness with a total effective rate of 82.5%.In the control group,23 cases had significant therapeutic effectiveness,28 cases had effectiveness and 24 cases had no effectiveness with a total effective rate of 67.0%.The comparative difference of the total effectiveness of the twogroups had statistical significance(x2 =4.40,P＜0.05).No other significant adverse reaction was found except several cases of light dizzy in the two groups. Conclusion Nicorandil has good therapeutic effective in treatment of angina pectoris and no significant adverse reaction.