异时性双侧原发乳腺癌48例临床分析

目的探讨异时性原发性双侧乳腺癌（mBPBC）的临床特征、治疗和预后。方法对48例mBPBC患者的临床资料进行回顾性分析。结果48例患者其中43例双侧均行改良根治术，5例第一侧乳腺癌行改良根治术，第二侧乳腺癌行保乳术。48例术后均进行了化疗，并根据淋巴结转移情况进行了放疗，根据雌激素受体和孕激素受体情况给予相应治疗。全组48例患者均进行了随访，按第二侧乳腺癌发现的时间算起，随访时间6～48个月，中位随访时间21．9个月。所有患者目前均存活，5例患者出现远处转移，其中3例患者出现纵膈淋巴结转移，2例患者出现肺转移。结论异时性原发性双侧乳腺癌应早期确诊，采取恰当的治疗方案，积极随访，可取得较好的治疗效果。

Clinical analysis of 48 patients with metachronous bilateral primary breast cancer

Objective To evaluate the characteristics,treatment and prognosis of metachronous bilateral primary breast cancer(mBPBC). Methods Clinical materials of 48 patients were performed with retrospective study. Results In 48 patients,43 cases taken both sides modified radical mastectomy and 5 cases taken lumpectomy and axillary dissection in the second side.All patients were treated with chemical treatment and treated with radiotherapy in accordance with lymph node metastasis.Besides a part of patients were treated with endocrine therapy in accordance with the expression of estrogen receptor(ER)and progesterone receptor(PR).The follow-up time was 6 ～ 48 months and the average time was 21.9 months.No died and 5 cases found distant metastasis. Conclusion mBPBC should be diagnosed earlier,taken appropriate treatment and followed up actively,so it would have a better therapeutic effect.