四种方法治疗食管胃底静脉曲张出血的疗效比较

目的比较四种方法治疗食管胃底静脉曲张出血的临床疗效及不良反应情况。方法对160例食管胃底静脉曲张出血患者的临床资料进行回顾性分析，其中40例给予奥曲肽联合硝酸甘油治疗（A组），40例单纯给予奥曲肽治疗（B组），40例给予奥曲肽联合垂体后叶素治疗（C组），40例给予垂体后叶素联合硝酸甘油治疗（D组），对比分析四组治疗的临床疗效及不良反应。结果A组和c组疗效（92．5％、90．0％）及平均止血时间（12．6±8．7）h、（13．2±8．4）h]明显优于B组和D组72．5％、62．5％，（17．6±10．2）h、（19．7±10．8）h]，差异均有统计学意义（X^2=5．54、4．05、10．32、8．35，t=2．1462、2．0326、2．7436、2．6324；均P〈0．05），A组和C组差异均无统计学意义（均P〉0．05）；A组和C组平均输血量（565±64）ml、（582±68）ml]明显低于B组和D组（775±78）ml、（967±86）ml]，差异均有统计学意义（t=3．8951、3．3642，6．4951、5．9724，均P〈0．05）；A组、B组不良反应发生率（5．0％、7．5％）明显低于C组、D组（27．5％、35．0％），差异均有统计学意义（X^2=7．44、11．25、5．54、9．04，均P〈0．05）。结论奥曲肽联合硝酸甘油治疗食管胃底静脉曲张出血临床疗效满意，且不良反应少，值得临床推广。

Clinical research of EGVB treatment with four different methods

Objective To compare the curative effect and untoward effect of EGVB treatment with four different methods. Methods The clinical information of 160 EGVB patients were analyzed,40 cases were treated by octreotide combined with glonoin( A group) ,40 cases were treated by octreotide( B group) ,40 cases were treated by octreotide combined with pituitrin ( C group) , 40 cases were treated by pituitrin combined with glonoin ( D group). Results Curative effect and average hemostasis time of A and C group were better than B and D group, average transfusion of A and C group were less than B and D group, untoward effect incidence rate of A and B group were less than C and D group. Conclusion Octreotide combined with glonoin have satisfied curative effect for EGVB patients, and had less untoward effect,it was worth generalizing.