早发型重度子痫前期分型与围产结局的关系

目的探讨早发型重度子痫前期的分型与围产结局的关系。方法80例早发型重度子痫前期患者以孕34周发病时间为界，分为早发突发型组（A组）14例和早发渐进型组（B组）66例，对两组患者的一般临床资料、并发症发生情况、围产结局及胎盘抑制素A、胎盘激活素A进行分析比较。结果80例中，早发突发型14例（17．5％）明显低于早发渐进型的66例（82．5％）（x^2=3．989，P〈0．05）；A组并发症发生率100．0％（14例），明显高于B组的27．3％（18例）（x^2=3．789，P〈0．05）；A组围生儿存活率27．3％，明显低于B组的79．3％（X^2=3．789，P〈0．05）；A组胎盘抑制素A、胎盘激活素A表达分别为（589．24±16．96）、（485．06±17．58），明显高于B组的（459．36±13．05）、（338．29±11．23）（t=2．424、2．439，均P〈0．05）；胎盘抑制素A、胎盘澉活素A表达水平与24h尿蛋白定量呈正相关（r=0．62、r=0．59，均P〈0．05）。结论早发突发型重度子痫前期患者临床上有不可预测性，其围产结局不良。

The relationship between the classification of early onset secere preeclampsia and perinatal outcomes

Objective To investigate the relationship between the classification of early onset secere preeclampsia and perinatal outcomes. Methods 80 patients with S-PE were divided into two groups;Early onset of S-PE (group A) 14 cases (onset≤ 34 weeks) and late onset of S-PE (group B) 66 cases (onset ＞34 weeks). The clinical data,complications,perinatal outcome and placental inhibin A,placenta activin A were compared. Results Among 80 cases with S-PE, 14 cases(17.5% ) in group A were significantly lower than the 66 cases(82.5% ) in group B( x2 = 3.989, P ＜ 0.05) ;The complication rate of 14 cases (100. 0% ) in group A were significantly higher than 18 cases (27. 3% ) in group B(x2 =3.989,P＜0.05) ;The perinatal survival rate of 27.3% in group A was significantly lower than 79.3% in group B(x2 = 3.789,P＜0. 01) ;The expression of placental inhibin A and placenta activin(589. 24 ± 16.96),(485.06 ±17. 58) in group A were significantly higher than (459. 36 ± 13. 05) , (338. 29 ± 11.23) in group B( t - 2.424,2.439, P ＜ 0.05) ; The expression of placental inhibin A and placenta activin with 24h urine protein(24h) were positively correlated(r = 0.62,0.59,all P＜0.05). Conclusion Early onset with S-PE were attacked abruptly and serious complications. It was significantly associated with poor maternal and perinatal outcomes.