初诊2型糖尿病患者大血管病变的危险因素分析

目的探讨初诊2型糖尿病（T2DM）患者大血管病变（MD）的相关危险因素。方法将符合条件的232例初诊T2DM患者根据有无MD分为两组：MD组与非MD组，对两组患者的多项临床指标进行比较及相关分析。结果（1）232例患者中，合并MD者95例，占40．9％。（2）MD组的年龄、体质量指数（BMI）、吸烟指数、收缩压、舒张压、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—C）、C反应蛋白（CRP）及24h尿微量白蛋白（24hUmAlb）均高于非MD组（均P〈0．05），而MD组的胰岛素敏感性指数（ISI）则低于非MD组（P〈0．05）。（3）Pearson相关分析提示MD与年龄、BMI、吸烟、收缩压、舒张压、LDL—Ch、CRP及24hUmAlb呈正相关。结论初诊T2DM患者合并MD与多种因素相关，须及早控制各种危险因素，以防止MD的发生、发展。

The Analysis for Macrovascular Disease in Newly Diagnosed Type 2 Diabetic Patients

Objective To investigate the risk factors associated with macrovascular disease in patients with newly-diagnosed type 2 diabetes. Methods According to arterial intima-media thickness(IMT)measured by color duplex ultrasonography,232 cases of newly-diagnosed type 2 diabetic patients were divided into two groups:one group were 95 cases with macrovascular disease(MD),and the other group were 137 cases without macrovascular disease (non-MD).Then various clinical data between the two groups were compared and the correlated risk factors for macrovascular disease were analyzed. Results (1)95 patients(40.9%)showed macrovascular disease in 232 patients.(2)Age,BMI,SI,systolic blood pressure,diastolic blood pressure,TC,LDL-C,CRP and 24h UmAlb were significantly higher in MD group compared with those in non-MD group(all P＜0.05);But ISI was significantly lower in MD group compared with that in non-MD group(P＜0.05).(3)Pearson correlation analysis showed that risk factors were old age,BMI,smoking,higher systolic blood pressure,higher diastolic blood pressure,TC,LDL-C,CRP and microalbuminuria. Conclusion Macrovascular disease was related to many factors.It was important to control some risk factors earlier for preventing the happening and progress of macrovascular disease.