原发性高血压患者血浆同型半胱氨酸水平变化及意义

目的探讨不同程度原发性高血压患者血浆同型半胱氨酸（Hey）水平变化及其临床意义。方法95例原发性高血压患者按照不同程度分成轻度高血压组（37例）、中度高血压组（30例）和重度高血压组（28例），另选65例同期健康体检正常者为对照组，采用荧光偏振免疫分析法测定血浆Hey水平并进行组间比较。结果对照组Hey水平（12．5±3．1）μmol／L，明显低于轻度高血压组的（15．4±4．8）μmol／L（t=-4．543，P〈0．01）、中度高血压组的（23．2±5．6）μmol／L（t=-14．291，P〈0．01）、重度高血压组的（28．1±6．7）μmol／L（t=-18．090，P〈0．01）；轻、中、重度高血压组间血浆Hey水平差异有统计学意义（F=118．550，P〈0．01）。结论高Hey是高血压发生发展的重要独立危险因素，可作为判定高血压病情严重程度的依据之一。

Correlation study of primary hypertension and plasma homocysteine

Objective To explore relationship among different degrees of hypertension and plasma homocysteine and their clinical significance. Methods According to ,95 hypertension patients were collected and divided into mild,moderate and severe groups,65 patients from the healthy check-up selected as control group, then the plasma Hcy level was measured and compared between the groups. Results Compared with the normal group ( 12. 5 ± 3. 1 ) μ mol/L, Hcy plasma levels of mild ( 15.4 ± 4. 8 ) μmol/L ( t = - 4. 543, P ＜ 0. 01 ), moderate ( 23.2 ± 5. 6 ) μmol/L ( t = - 14. 291, P ＜ 0. 01 ), severe (28. 1 ± 6. 7) μmol/L( t = - 18. 090,P ＜0. 01 ) hypertension group increased significantly,severe group was obviously higher than patients among moderate group,moderate group was significantly higher than patients among mild group,statistical significance among different groups were found( F = 118. 550, P ＜ 0. 01 ). Conclusion High Hcy was an important independent risk factor,the monitoring of plasma homocysteine level for hypertension contribute to diagnosis and understand disease progression.