Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression |
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Authors: | Katharine Martin Runa Sur Frank Liebel Neena Tierney Peter Lyte Michelle Garay Thierry Oddos Mike Anthonavage Stan Shapiro Michael Southall |
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Institution: | (1) Johnson & Johnson Skin Research Center, CPPW, a unit of Johnson & Johnson Consumer Companies, Inc., Skillman, NJ, USA;(2) Johnson & Johnson Skin Research Center, CPPW, a unit of Johnson & Johnson Consumer Companies, Inc., Val de Reuil, France;(3) Johnson & Johnson Consumer and Personal Products Worldwide, 199 Grandview Road, Skillman, NJ 08558, USA |
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Abstract: | The skin is under continual assault from a variety of damaging environmental factors such as ultraviolet irradiation and atmospheric
pollutants, and as organisms age the cumulative damage exceeds the capacity of endogenous antioxidant defenses resulting in
chronic inflammation and premature aging. Botanical extracts such as Feverfew containing naturally occurring antioxidants
could replenish the depleted cutaneous stores and perhaps forestall these degenerative changes. A parthenolide-depleted extract
of Feverfew (PD-Feverfew), which was free of sensitization potential, was found to possess free radical scavenging activity
against a wide range of reactive oxygen species and with greater activity than Vitamin C. In vitro, PD-Feverfew restored cigarette
smoke-mediated depletion of cellular thiols, attenuated the formation of UV-induced hydrogen peroxide and reduced pro-inflammatory
cytokine release. In vivo, topical PD-Feverfew reduced UV-induced epidermal hyperplasia, DNA damage and apoptosis. In a clinical
study PD-Feverfew treatment significantly reduced erythema versus placebo 24 h post-UV exposure. Through the ability to scavenge
free radicals, preserve endogenous antioxidant levels, reduce DNA damage and induce DNA repair enzymes, which can help repair
damaged DNA, parthenolide-depleted extract of Feverfew may protect skin from the numerous external aggressions encountered
daily by the skin and reduce the damage to oxidatively challenged skin. |
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Keywords: | Feverfew Flavonoids Oxidative stress Parthenolide Reactive oxygen species Inflammation |
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