Erectile dysfunction as a coronary artery disease risk equivalent |
| |
Authors: | John H Lee MD Raphael Ngengwe MD Philip Jones MS Fengming Tang MS James H O’Keefe MD |
| |
Institution: | aMid America Heart Institute, Kansas City, Mo;bUniversity of Missouri-Kansas City, Kansas City, Mo |
| |
Abstract: | Background. The conditions that predispose patients to erectile dysfunction are substantially similar to the coronary artery disease
risk factors, including diabetes mellitus, hypertension, hyperlipidemia, obesity, sedentary lifestyle, depression, age, and
smoking. Because of these shared risks and overlapping pathophysiologic mechanisms, we designed this pilot study to address
the hypothesis that the presence of coronary artery calcium, a known indicator of increased cardiac risk, is associated with
erectile dysfunction.
Methods and Results. A prospective registry enrolled 9150 men who underwent multidetector computed tomography. Subjects supplied baseline data
regarding demographic variables, coronary risk factors, and erectile dysfunction symptoms or lack thereof. The 2 groups then
underwent computed tomography to screen for the presence or absence of coronary artery calcium. Subjects with erectile dysfunction
were older, had higher triglyceride levels, had higher blood pressures, and were more likely to have measurable coronary artery
calcification than men without erectile dysfunction (79% vs 58%,P<.001).
Conclusion. Erectile dysfunction is significantly associated with abnormal coronary artery calcification and, like peripheral arterial
disease, might warrant consideration as a coronary artery disease risk equivalent. |
| |
Keywords: | Erectile dysfunction cardiovascular disease coronary artery calcium score multidetector computed tomography |
本文献已被 ScienceDirect SpringerLink 等数据库收录! |
|