| 基于HIS数据库分析疏血通注射液对血尿素氮异常变化率的影响 |
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| 引用本文： | 支英杰,杨伟,谢雁鸣,张辉,杨虎,庄严. 基于HIS数据库分析疏血通注射液对血尿素氮异常变化率的影响[J]. 中国中药杂志, 2013, 38(18): 3048-3052 |
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| 作者姓名： | 支英杰 杨伟 谢雁鸣 张辉 杨虎 庄严 |
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| 作者单位： | 中国中医科学院 中医临床基础医学研究所, 北京 100700;中国中医科学院 中医临床基础医学研究所, 北京 100700;中国中医科学院 中医临床基础医学研究所, 北京 100700;中国人民大学 统计学院, 北京 100872;中国人民大学 统计学院, 北京 100872;中国人民解放军 海军总医院, 北京 100048 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09502-030);国家自然科学基金青年基金项目(81202776);中国中医科学院第7批自主选题项目(Z0255);中国中医科学院客座研究员联合创新研究项目(ZZ070817) |
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| 摘 要： | 目的: 分析医院信息管理系统(hospital information system,HIS)中使用疏血通注射液(以下简称疏血通)患者的血尿素氮(BUN)异常变化率的情况,从而为临床安全使用疏血通提供一定的参考与借鉴。 方法: 选择全国18家三甲医院HIS中使用疏血通的住院患者信息,采用集成数据仓库构建模式处理数据,基于GBM倾向评分法,利用Logistic回归方法对数据进行分析。 结果: Logistic回归分析的数据结果显示病例组和对照组BUN异常变化率存在统计学差异(P<0.05);但通过GBM倾向评分法平衡混杂后的Logistic回归分析结果显示2组BUN异常变化率无统计学差异。 结论: GMB倾向评分法能有效地均衡各组间混杂变量的分布,以使研究结果更贴近实际情况;对真实世界中HIS数据的混杂偏倚进行平衡后,疏血通对BUN的异常变化率没有显著影响,该结果仍期待大样本前瞻性随机对照试验数据的支持。
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| 关 键 词： | 疏血通 HIS 数据库 GBM倾向评分法 血尿素氮 |
| 收稿时间： | 2013-05-08 |
Impact analysis of parenterally administered Shuxuetong on abnormal changes of BUN index based on hospital information system data |
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| ZHI Ying-jie,YANG Wei,XIE Yan-ming,ZHANG Hui,YANG Hu and ZHUANG Yan. Impact analysis of parenterally administered Shuxuetong on abnormal changes of BUN index based on hospital information system data[J]. China Journal of Chinese Materia Medica, 2013, 38(18): 3048-3052 |
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| Authors: | ZHI Ying-jie YANG Wei XIE Yan-ming ZHANG Hui YANG Hu ZHUANG Yan |
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| Affiliation: | Institute of Basic Research in Clinical Medcine, China Academy of Medical Sciences, Beijing 100700, China;Institute of Basic Research in Clinical Medcine, China Academy of Medical Sciences, Beijing 100700, China;Institute of Basic Research in Clinical Medcine, China Academy of Medical Sciences, Beijing 100700, China;School of Statistics, Renmin University of China, Beijing 100872, China;School of Statistics, Renmin University of China, Beijing 100872, China;The PLA Navy General Hospital, Beijing 100048, China |
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| Abstract: | Objective: To estimate real world treatment effects of parenterally administered Shuxuetong on abnormal changes in blood urea nitrogen (BUN) index, inorder to to explore whether parenterally administered Shuxuetong affects kidney function and to provide clinical guidance for its safe application. Method: Analyze hospital information system(HIS) data and laboratory information management system (LIS) data from 18 nationawide general hospitals in china. A retrospective cohort study with two cohorts of patients, assessing abnormal changes of BUN index as an outcome, confounding factors are balanced through use of generalized boosted models(GBM) and multiple logistic regression based on adjusted propensity score to estimate treatment effects of parenterally administered Shuxuetong on abnormal changes of BUN index and to explore possible influencing factors. Result: Logistic regression based on adjusted propensity score results showed that there was a statistically significant difference(P<0.05), in abnormal BUN in rates between the two groups. However, the GBM propensity score method showed that abnormal BUN rates were not statistically significantly different between the two groups. Conclusion: Based on large sample clinical observational data from HIS and LIS database, significant effects of parenterally administered Shuxuetong on abnormal changes of BUN have not been found. The generalized boosted models (GBM) method is more suitable for retrospective non-randomized observational data. These results should be confirmed through largescale prospective randomized controlled trials. |
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| Keywords: | parenterally administered Shuxuetong hospital information system generalized boosted models BUN |
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