| 吉林人参根和根茎的化学成分研究 |
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| 引用本文： | 王洪平,杨鑫宝,杨秀伟,刘建勋,王英平,张连学.吉林人参根和根茎的化学成分研究[J].中国中药杂志,2013,38(17):2807-2817. |
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| 作者姓名： | 王洪平 杨鑫宝 杨秀伟 刘建勋 王英平 张连学 |
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| 作者单位： | 北京大学 药学院 天然药物及仿生药物国家重点实验室, 北京 100191;中国中医科学院 西苑医院, 北京 100091;北京中医药大学, 北京 100029;北京大学 药学院 天然药物及仿生药物国家重点实验室, 北京 100191;中国中医科学院 西苑医院, 北京 100091;北京中医药大学, 北京 100029;中国农业科学院 特产研究所, 长春 130122;吉林农业大学 中药材学院, 长春 130118 |
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| 基金项目： | 国家自然科学基金项目(30830118);国家"十二五"科技支撑专项(2011BAI03B01,2011BAI07B08) |
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| 摘 要： | 采用Amberlite XAD-4大孔吸附树脂和硅胶柱色谱以及高效液相色谱等方法系统性研究人参根和根茎的化学成分;通过谱学数据分析鉴定化合物的结构。从人参根和根茎的70%乙醇提取物中分离得到28个皂苷类化合物,分别鉴定为高丽人参皂苷R1(1),人参皂苷Rg1(2),人参皂苷Rf(3),三七皂苷R2(4),人参皂苷Rg2(5),三七皂苷Fe(6),吉林人参苷醇(7),人参皂苷Re5(8),三七皂苷N(9),三七皂苷R1(10),人参皂苷Re2(11),人参皂苷Re1(12),人参皂苷Re(13),人参皂苷Rs2(14),人参皂苷Ro甲酯(15),人参皂苷Rd(16),人参皂苷Re3(17),人参皂苷Re4(18),20-葡萄糖基-人参皂苷Rf(19),人参皂苷Ro(20),人参皂苷Rc(21),西洋参皂苷R1(22),人参皂苷Ra2(23),人参皂苷Rb1(24),人参皂苷Ra1(25),人参皂苷Ra3(26),人参皂苷Rb2(27),三七皂苷R4(28)。所有化合物均系20(S)-原人参二醇型或原人参三醇型皂苷。化合物1为首次从吉林栽培人参根和根茎中分离得到;化合物6为首次从人参根和根茎中分离得到;并首次对化合物6,14,19的氢谱信号进行了归属。
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| 关 键 词： | 人参 化学成分 三七皂苷Fe 人参皂苷Rs2 20-葡萄糖基-人参皂苷Rf |
| 收稿时间： | 2013/3/17 0:00:00 |
Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province |
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| WANG Hong-ping,YANG Xin-bao,YANG Xiu-wei,LIU Jian-xun,WANG Ying-ping and ZHANG Lian-xue.Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province[J].China Journal of Chinese Materia Medica,2013,38(17):2807-2817. |
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| Authors: | WANG Hong-ping YANG Xin-bao YANG Xiu-wei LIU Jian-xun WANG Ying-ping and ZHANG Lian-xue |
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| Institution: | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;Xiyuan Hospital, China Academy of Chinese Sciences, Beijing 100091, China;Beijing University of Chinese Medicines, Beijing 100029, China;State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;Xiyuan Hospital, China Academy of Chinese Sciences, Beijing 100091, China;Beijing University of Chinese Medicines, Beijing 100029, China;Institute of Special Wild Economic Animals and Plants Science, Chinese Academy of Agricultural Sciences, Changchun 130122, China;College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China |
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| Abstract: | The chemical constituents of the roots and rhizomes of Panax ginseng were systematically investigated by various column chromatographic methods including Amberlite XAD-4 macroporous adsorptive resins and silica gel as well as high-performance liquid chromatography, and their chemical structures were identified by physico-chemical properties and spectral analyses. Twenty-eight compounds were isolated from the 70% ethanolic-aqueous extract and identified as koryoginsenoside R1(1), ginsenoside Rg1(2), ginsenoside Rf(3), notoginsenoside R2(4), ginsenoside Rg2(5), notoginsenoside Fe(6), ginsenjilinol(7), ginsenoside Re5(8), notoginsenoside N(9), notoginsenoside R1(10), ginsenoside Re2(11), ginsenoside Re1(12), ginsenoside Re(13), ginsenoside Rs2(14), ginsenoside Ro methyl ester(15), ginsenoside Rd(16), ginsenoside Re3(17), ginsenoside Re4(18), 20-gluco-ginsenoside Rf(19), ginsenoside Ro(20), ginsenoside Rc(21), quinquenoside-R1(22), ginsenoside Ra2(23), ginsenoside Rb1(24), ginsenoside Ra1(25), ginsenoside Ra3(26), ginsenoside Rb2(27), and notoginsenoside R4(28). All isolated compounds are 20(S)-protopanaxadiol or protopanaxatriol type triterpenoid saponins. Compound 1 was isolated from the roots and rhizomes of P. ginseng cultivated in Jilin province for the first time and compound 6 was isolated from the roots and rhizomes of P. ginseng for the first time. The 1H-NMR data of compounds 6, 14 and 19 were assigned for the first time. |
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| Keywords: | Panax ginseng chemical constituents notoginsenoside Fe ginsenoside Rs2 20-gluco-ginsenoside Rf |
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