慢性咳嗽病因分布的初步调查

目的 了解上海地区慢性咳嗽病因分布的特点.方法 以中华医学会制定的<咳嗽的诊断与治疗指南>(2009版)中慢性咳嗽诊断流程为指导,对98例咳嗽时间≥8周的患者进行病因分析、咳嗽症状积分、视觉模拟评分及Leicester咳嗽问卷调查.结果 98例患者中明确咳嗽病因诊断94例(95.92%),病因未明者4例(4.08%).94例患者中,单一病因82例(87.23%),双重病因12例(12.77%).咳嗽病因包括咳嗽变异性哮喘(CVA)44例(40.00%),上气道咳嗽综合征(UACS)28例(25.45%),嗜酸粒细胞性支气管炎(EB)21例(19.08%),变应性咳嗽5例(4.55%),胃食管反流性咳嗽4例(3.64%),感染后咳嗽3例(2.73%).治疗前后咳嗽积分、视觉模拟评分及Leicester咳嗽积分比较差异有统计学意义(P＜0.05).结论 CVA、UACS和EB是上海地区慢性咳嗽的常见原因.

Preliminary investigation on etiological diagnosis of chronic cough in Shanghai region

Objective To investigate the causes of chronic cough in Shanghai region. Methods All the cases were diagnosed using a diagnostic protocol designed by Chinese Medical Association. All patients completed cough scores,visual analogue scales and Leicester Cough Questionnaire (LCQ). Results The causes of chronic cough were confirmed in 94 patients (95.92%). Four patients had not been definitely diagnosed (4.08%). Cough due to single cause was found in 82 patients (87.23 % ), and due to double causes in 12 patients (12.77%). The causes included cough variant asthma (CVA) in 44 patients (40.00 % ), upper airway cough syndrome (UACS) in 28 patients ( 25.45 % ), eosinophilic bronchitis (EB)in 21 patients( 19.08% ) ,atopic cough in 5 patients (4.55%) ,gastro-esophageal reflux cough in 4 patients (3.64%), post infection cough in 3 patients (2.73%), chronic bronchitis in 1 patient (0.91%),respectively. There were significant differences in cough scores,visual analogue scales and LCQ between prior-treatment and post-treatment. Conclusions CVA, UACS and EB are the main causes of chronic cough in shanghai region.